지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 65 - 73 (9page)
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초록· 키워드
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Background: Hair loss and hair growth is the subject of tremendous amount of research. Objective: This study investigated the efficacy of three chemical treatments used in humans for hair loss, using a rat model of hair regrowth. The products tested were 2% minoxidil, Hairgrow (Dar-Al-Dawa Pharma), Aminexil, Dercos (Vichy Laboratoires), and Kerium, Anti-chute (La Roche-Posay). Methods: Thirty-two adult female Wistar-Bratislava rats were assigned to 4 groups.
Two rectangular areas (2×4 cm) were shaved on either sides of the mid dorsal line (left side - control; right side - test area).
Group I was treated topically with 2% minoxidil, group II with Aminexil, and group III with Kerium. Each rat received 0.3 ml of substance applied topically to the shaved dorsal skin every day for 28 days. Rats in group IV served as sham controls receiving no treatment. Hair regrowth was evaluated by trichoscopy (with a dermatoscope), grown hair weight (from a surface area of 1 cm2), and histopathological examination for skin thickness, follicle count, and percentage of anagen induction (morphometric assessment). Results: Treatment with 2% minoxidil significantly induced hair regrowth as assessed by trichoscopy, hair weight examination, and morphometric evaluation. Hair weight examination and morphometric assessment demonstrated the lowest hair growth effect with Aminexil among the tested products.
Treatment with Kerium was found to significantly induce hair regrowth (p＜0.05 as compared to the control group).
Conclusion: Our study demonstrates that hair regrowth efficacy of products recommended for human use is not similar when tested on an animal model.
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등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Cash TF / 2001 / The psychology of hair loss and its implications for patient care / Clin Dermatol 19:161~166
Stough D. / 2005 / Psychological effect, pathophysiology, and management of androgenetic alopecia in men / Mayo Clin Proc 80:1316~1322
Hadshiew IM. / 2004 / Burden of hair loss : stress and the underestimated psychosocial impact of telogen effluvium and androgenetic alopecia / J Invest Dermatol 123:455~457
Cash TF. / 1993 / Psychological effects of androgenetic alopecia on women : comparisons with balding men and with female control subjects / J Am Acad Dermatol 29:568~575
Poulos GA. / 2005 / Investigational medications in the treatment of alopecia / Expert Opin Investig Drugs 14:177~184
Stough D. / 2005 / Psychological effect, pathophysiology, and management of androgenetic alopecia in men / Mayo Clin Proc 80:1316~1322
Hadshiew IM. / 2004 / Burden of hair loss : stress and the underestimated psychosocial impact of telogen effluvium and androgenetic alopecia / J Invest Dermatol 123:455~457
Cash TF. / 1993 / Psychological effects of androgenetic alopecia on women : comparisons with balding men and with female control subjects / J Am Acad Dermatol 29:568~575
Poulos GA. / 2005 / Investigational medications in the treatment of alopecia / Expert Opin Investig Drugs 14:177~184
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