지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives: This aim of this study is to compare the reflux esophagitis improvement effects of Sepiae Os, Arcae Concha, Ostreae Concha, and Proton Pump Inhibitor(esomeprazole) through rat experiments.
Methods: NO production inhibitory effect was measured by NO production amount and iNOS mRNA expression level in cell lines. iNOS, TNF-α and p-IκB, and serotonin were compared using immunohistochemistry at the rat reflux esophagitis. Reflux esophagitis connection external form, lower esophageal sphincter, and gap were observed and an esophageal inflammatory indicator, IL-6 activity was also evaluated by immunohistochemistry.
Results: NO production and iNOS mRNA expression was showed concentration dependent decrease in cell lines treated with Sepiae OS, Arcae Concha, and Ostreae Concha at the experiments of cell lines. In the suppression of iNOS and p-IκB at the rat reflux esophagitis, Sepiae Os treat group(SOT) and Ostreae Concha treat group(OCT) were more effective. In the increase of serotonin at the rat reflux esophagitis, ACT, MT and OCT were more effective. Damage of lower esophageal sphincter, and gap between esophageal keratin and mucosa were observed less at the SOT, ACT, OCT. In the suppression of IL-6 at the rat reflux esophagitis, SOT and OCT were more effective than GE and, SOT was more effective than MT significantly.
Conclusions: The anti-inflammatory effect was the best in the SOT and lower esophageal sphincter muscle contraction was the best in the ACT at the rat reflux esophagitis. Sepiae OS was more effective than esomeprazole in the suppression of iNOS, TNF-α, and IL-6.
Methods: NO production inhibitory effect was measured by NO production amount and iNOS mRNA expression level in cell lines. iNOS, TNF-α and p-IκB, and serotonin were compared using immunohistochemistry at the rat reflux esophagitis. Reflux esophagitis connection external form, lower esophageal sphincter, and gap were observed and an esophageal inflammatory indicator, IL-6 activity was also evaluated by immunohistochemistry.
Results: NO production and iNOS mRNA expression was showed concentration dependent decrease in cell lines treated with Sepiae OS, Arcae Concha, and Ostreae Concha at the experiments of cell lines. In the suppression of iNOS and p-IκB at the rat reflux esophagitis, Sepiae Os treat group(SOT) and Ostreae Concha treat group(OCT) were more effective. In the increase of serotonin at the rat reflux esophagitis, ACT, MT and OCT were more effective. Damage of lower esophageal sphincter, and gap between esophageal keratin and mucosa were observed less at the SOT, ACT, OCT. In the suppression of IL-6 at the rat reflux esophagitis, SOT and OCT were more effective than GE and, SOT was more effective than MT significantly.
Conclusions: The anti-inflammatory effect was the best in the SOT and lower esophageal sphincter muscle contraction was the best in the ACT at the rat reflux esophagitis. Sepiae OS was more effective than esomeprazole in the suppression of iNOS, TNF-α, and IL-6.
목차
서론
재료 및 방법
실험결과
고찰
결론
참고문헌
참고문헌 (46)
참고문헌 신청
[단행본] - National Professors of Bikye Internal Medicine / 2009 / Bikye Internal Medicine / Kunja Publisher : 96 ~
[학술지(정기간행물)] - Cho YS / 2005 / Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Asan-si, Korea / Am J Gastroenterol 100 : 747 ~ 753
[학술지(정기간행물)] - Lee D / 2013 / Prevalence of asymptomatic erosive esophagitis and factors associated with symptom presentation of erosive esophagitis / Scand J Gastroenterol 48 : 906 ~ 912
[학술지(정기간행물)] - 김지현 / 2014 / 위식도역류질환의 최근 동향 / 대한소화기학회지 64 (3) : 127 ~ 132
[학술지(정기간행물)] - 정혜경 / 2012 / 위식도역류질환 임상진료지침 개정안 2012 / 대한소화기학회지 60 (4) : 195 ~ 218
[학술지(정기간행물)] - Cho YS / 2005 / Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Asan-si, Korea / Am J Gastroenterol 100 : 747 ~ 753
[학술지(정기간행물)] - Lee D / 2013 / Prevalence of asymptomatic erosive esophagitis and factors associated with symptom presentation of erosive esophagitis / Scand J Gastroenterol 48 : 906 ~ 912
[학술지(정기간행물)] - 김지현 / 2014 / 위식도역류질환의 최근 동향 / 대한소화기학회지 64 (3) : 127 ~ 132
[학술지(정기간행물)] - 정혜경 / 2012 / 위식도역류질환 임상진료지침 개정안 2012 / 대한소화기학회지 60 (4) : 195 ~ 218
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