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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 910 - 916 (7page)
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초록· 키워드
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Background/Aims: To investigate the effects of esomeprazole and rebamipide combination therapy on symptomatic improvement in patients with reflux esophagitis. Methods: A total of 501 patients with reflux esophagitis were randomized into one of the following two treatment regimens: 40 mg esomeprazole plus 300 mg rebamipide daily (combination therapy group) or 40 mg esomeprazole daily (monotherapy group). We used a symptom questionnaire that evaluated heartburn, acid regurgitation, and four upper gastrointestinal symptoms. The primary efficacy end point was the mean decrease in the total symptom score. Results: The mean decreases in the total symptom score at 4 weeks were estimated to be -18.1±13.8 in the combination therapy group and -15.1±11.9 in the monotherapy group (p=0.011).
Changes in reflux symptoms from baseline after 4 weeks of treatment were -8.4±6.6 in the combination therapy group and -6.8±5.9 in the monotherapy group (p=0.009). Conclusions: Over a 4-week treatment course, esomeprazole and rebamipide combination therapy was more effective in decreasing the symptoms of reflux esophagitis than esomeprazole monotherapy.
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참고문헌 (34)
참고문헌 신청
Dray A / 1995 / Inflammatory mediators of pain / Br J Anaesth 75:125~131
Yoshida N / 2004 / Interleukin-8 expression in the esophageal mucosa of patients with gastroesophageal reflux disease / Scand J Gastroenterol 39:816~822
Labenz J / 2005 / A randomized comparative study of esomeprazole 40 mg versus pantoprazole 40 mg for healing erosive oesophagitis: the EXPO study / Aliment Pharmacol Ther 21:739~746
Bochenek WJ / 2004 / Pantoprazole provides rapid and sustained symptomatic relief in patients treated for erosive oesophagitis / Aliment Pharmacol Ther 20:1105~1114
Arakawa T / 2005 / 15th anniversary of rebamipide: looking ahead to the new mechanisms and new applications / Dig Dis Sci 50(1):S3~S11
Yoshida N / 2004 / Interleukin-8 expression in the esophageal mucosa of patients with gastroesophageal reflux disease / Scand J Gastroenterol 39:816~822
Labenz J / 2005 / A randomized comparative study of esomeprazole 40 mg versus pantoprazole 40 mg for healing erosive oesophagitis: the EXPO study / Aliment Pharmacol Ther 21:739~746
Bochenek WJ / 2004 / Pantoprazole provides rapid and sustained symptomatic relief in patients treated for erosive oesophagitis / Aliment Pharmacol Ther 20:1105~1114
Arakawa T / 2005 / 15th anniversary of rebamipide: looking ahead to the new mechanisms and new applications / Dig Dis Sci 50(1):S3~S11
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