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논문 기본 정보

자료유형
학술저널
저자정보
Mehdy Ghaeminia (National University Health System) Ramamoorthy Rajkumar (National University Health System) Hwee-Ling Koh (National University of Singapore) Gavin S. Dawe (National University Health System) Chay Hoon Tan (National University Health System)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.42 No.3
발행연도
2018.6
수록면
298 - 303 (6page)

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초록· 키워드

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Background: Panax ginseng is one of the most commonly used medicinal herbs worldwide for a variety of therapeutic properties including neurocognitive effects. Ginsenoside Rg1 is one of the most abundant active chemical constituents of this herb with known neuroprotective, anxiolytic, and cognition improving effects.
Methods: We investigated the effects of Rg1 on the medial prefrontal cortex (mPFC), a key brain region involved in cognition, information processing, working memory, and decision making. In this study, the effects of systemic administration of Rg1 (1 mg/kg, 3 mg/kg, or 10 mg/kg) on (1) spontaneous firing of the medial prefrontal cortical neurons and (2) long-term potentiation (LTP) in the hippocampalemedial prefrontal cortical (HPemPFC) pathway were investigated in male SpragueeDawley rats.
Results: The spontaneous neuronal activity of approximately 50% the recorded pyramidal cells in the mPFC was suppressed by Rg1. In addition, Rg1 attenuated LTP in the HPemPFC pathway. These effects were not dose-dependent.
Conclusion: This report suggests that acute treatment of Rg1 impairs LTP in the HPemPFC pathway, perhaps by suppressing the firing of a subset of mPFC neurons that may contribute to the neurocognitive effects of Rg1.

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ABSTRACT
1. Introduction
2. Material and methods
3. Results
4. Discussion
References

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UCI(KEPA) : I410-ECN-0101-2018-524-003161160