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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.7
- 수록면
- 241 - 247 (7page)
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초록· 키워드
오류제보하기
Lactobacillus (LAB) have been reported to exert both harmful and beneficial effects on human and animal health. Recently, it has been reported that dysbiosis and bacterial translocation contribute to liver fibrosis. However, the role of Gram-positive LAB in the situation of chronic liver diseases has not been yet elucidated. Liver injury was induced by bile duct ligation (BDL) in LAB or control-administered mice. Liver fibrosis was enhanced in LABadministered mice compared with control-treated mice as demonstrated by quantification of Sirius-red positive area, hydroxyproline contents and fibrosis-related genes (Col1α1, Acta2, Timp1, Tgfb1). Moreover, LAB-administered mice were more susceptible to BDL-induced liver injury as shown by increased ALT and AST level of LAB group compared with control group at 5 days post BDL. Consistent with serum level, inflammatory cytokines (TNF-α, IL-6 and IL-1β) were also significantly increased in LAB-treated mice. Of note, LAB-treated liver showed increased lipoteichoic acid (LTA) expression compared with control-treated liver, indicating that LABderived LTA may translocate from intestine to liver via portal vein. Indeed, responsible receptor or inflammatory factor (PAFR and iNOS) for LTA were upregulated in LAB-administered group. The present findings demonstrate that administration of LAB increases LTA translocation to liver and induces profibrogenic inflammatory milieu, leading to aggravation of liver fibrosis. The current study provides new cautious information of LAB for liver fibrosis patients to prevent the detrimental effect of LAB supplements.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (19)
참고문헌 신청
Hempel, S. / 2011 / Safety of probiotics used to reduce risk and prevent or treat disease / Evid. Rep. Technol. Assess. (Full Rep.) 200:1~645
Vaarala, O. / 2003 / Immunological effects of probiotics with special reference to lactobacilli / Clin. Exp. Allergy 33:1634~1640
Veckman, V. / 2004 / Streptococcus pyogenes and Lactobacillus rhamnosus differentially induce maturation and production of Th1-type cytokines and chemokines in human monocyte-derived dendritic cells / J. Leukoc. Biol. 75:764~771
Braat, H. / 2004 / Dichotomy between Lactobacillus rhamnosus and Klebsiella pneumoniae on dendritic cell phenotype and function / J. Mol. Med. (Berl.) 82:197~205
Drakes, M. / 2004 / Bacterial probiotic modulation of dendritic cells / Infect. Immun. 72:3299~3309
Vaarala, O. / 2003 / Immunological effects of probiotics with special reference to lactobacilli / Clin. Exp. Allergy 33:1634~1640
Veckman, V. / 2004 / Streptococcus pyogenes and Lactobacillus rhamnosus differentially induce maturation and production of Th1-type cytokines and chemokines in human monocyte-derived dendritic cells / J. Leukoc. Biol. 75:764~771
Braat, H. / 2004 / Dichotomy between Lactobacillus rhamnosus and Klebsiella pneumoniae on dendritic cell phenotype and function / J. Mol. Med. (Berl.) 82:197~205
Drakes, M. / 2004 / Bacterial probiotic modulation of dendritic cells / Infect. Immun. 72:3299~3309
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