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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 188 - 188 (1page)
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Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease, and its significant risk of steatohepatitis and liver fibrosis can result in cirrhosis and liver cancer. TAK1 (MAP3K7) is a MAP3K of TLRs, IL-1, TNF and TGF-β receptor signaling. In a previous study, we have been reported MAP3K7 protects against hepatocyte death, inflammation and fibrosis. Currently, we studied the mechanism how MAP3K7 affects on steatosis-associated liver fibrosis. Interestingly we found that liver of HFD+CCl4-treated mice have significantly decreased expression of MAP3K7 compared with those of LFD+CCl4 treated mice. These results are consistent with data showing reduced expression of MAP3K7 in (O ... 전체 초록 보기
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