지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.7
- 수록면
- 471 - 481 (11page)
- DOI
- 10.11002/kjfp.2018.25.4.471
이용수
초록· 키워드
오류제보하기
Dendropanax morbifera Léveille (Araliaceae) is an endemic species growing in the south-western part of South Korea and has been used in folk medicine and health functional food. Several studies have indicated that extract of D. morbifera (DP) has cytotoxic activities on a number of human cancers, such as, breast cancer, lung cancer, hepatoma, and chorioepithelioma. Recently, polyacetylene and triterpene compounds have been isolated from the DP and showed to have anti-complement activity. β-Amyrin, α-amyrin, dendropanoxide, and β-sitosterol are isolated from DP. However, its biological activities in cancer have not yet been clearly elucidated. In this study, we evaluated the anti-cancer activity of isolated triterpenoids from the DP leaves by measuring the levels of cytotoxicity against MCF-7 human breast cancer and A549 human lung cancer cells. Six triterpenoids were isolated from the n-hexane
fraction of DP leaves along with the known compounds. β-amyrin (1), α-amyrin (2), olean-12-en-3,24 β-diol (3), dendropanoxide (4), β-sitosterol (5), and stigmasterol (6). Compound 3 and 6 were isolated from DP for the first time. Cytotoxic activities of six compounds were evaluated against two human cancer cell lines by using the MTT in vitro assay. Among them, five compounds (1, 2, 4, 5, and 6) showed moderate cytotoxic activities toward the tested cell lines, and were safe to normal cells. Western blot analysis showed a decreased expression of anti-apoptotic protein Bcl-2 and increased levels of pro-apoptotic protein Bax in MCF-7 and A549 cells treated by β-amyrin and α-amyrin. Flow cytometry analysis confirmed that five compounds (1, 2, 4, 5, and 6) treatment increased populations of sub-G1 (apoptosis) phase. The results of the present study revealed that triterpenoids from DP have the potential for further development as anticancer agents.
fraction of DP leaves along with the known compounds. β-amyrin (1), α-amyrin (2), olean-12-en-3,24 β-diol (3), dendropanoxide (4), β-sitosterol (5), and stigmasterol (6). Compound 3 and 6 were isolated from DP for the first time. Cytotoxic activities of six compounds were evaluated against two human cancer cell lines by using the MTT in vitro assay. Among them, five compounds (1, 2, 4, 5, and 6) showed moderate cytotoxic activities toward the tested cell lines, and were safe to normal cells. Western blot analysis showed a decreased expression of anti-apoptotic protein Bcl-2 and increased levels of pro-apoptotic protein Bax in MCF-7 and A549 cells treated by β-amyrin and α-amyrin. Flow cytometry analysis confirmed that five compounds (1, 2, 4, 5, and 6) treatment increased populations of sub-G1 (apoptosis) phase. The results of the present study revealed that triterpenoids from DP have the potential for further development as anticancer agents.
목차
Abstract
Introduction
Materials and methods
Results and discussion
Summary
References
참고문헌 (46)
참고문헌 신청
[학술지(정기간행물)] - Merghoub N / 2009 / Cytotoxic effect of some Moroccan medicinal plant extracts on human cervical cell lines / J Med Plants Res 3 : 1045 ~ 1050
[학술지(정기간행물)] - Fridlender M / 2015 / Plant derived substances with anti-cancer activity: from folklore to practice / Front Plant Sci 6 : 1 ~ 9
[학술지(정기간행물)] - Khazaei S / 2017 / Flower extract of Allium atroviolaceum triggered apoptosis, activated caspase-3 and down-regulated antiapoptotic Bcl-2 gene in HeLa cancer cell line / Biomed Pharmacother 89 : 1216 ~ 1226
[학술지(정기간행물)] - Xu W / 2008 / Kaempferol-7-O-${\beta}$ -D-glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner / Cancer Lett 264 : 229 ~ 240
[학술지(정기간행물)] - Dwivedi V / 2011 / Cytotoxic potential of Indian spices (extracts) against esophageal squamous carcinoma cells / Asian Pac J Cancer Prev 12 : 2069 ~ 2073
[학술지(정기간행물)] - Fridlender M / 2015 / Plant derived substances with anti-cancer activity: from folklore to practice / Front Plant Sci 6 : 1 ~ 9
[학술지(정기간행물)] - Khazaei S / 2017 / Flower extract of Allium atroviolaceum triggered apoptosis, activated caspase-3 and down-regulated antiapoptotic Bcl-2 gene in HeLa cancer cell line / Biomed Pharmacother 89 : 1216 ~ 1226
[학술지(정기간행물)] - Xu W / 2008 / Kaempferol-7-O-
[학술지(정기간행물)] - Dwivedi V / 2011 / Cytotoxic potential of Indian spices (extracts) against esophageal squamous carcinoma cells / Asian Pac J Cancer Prev 12 : 2069 ~ 2073
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