지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The innate immune recognition is based on the detection of microbial products. Toll-like receptors (TLRs) located on the cell surface and the endosome senses microbial components and nucleic acids, respectively. Chicken TLRs mediate immune responses by sensing ligands from pathogens, have been studied as immune adjuvants to increase the efficacy of vaccines. Single nucleotide polymorphisms (SNPs) of TLR3 and TLR4 genes in chicken were associated with resistance and susceptibility to viral infection. In this study, SNPs of chTLR3 and chTLR4 genes were retrieved from public database and annotated with chicken reference genome. Three-dimensional models of the chTLR3 and chTLR4 proteins were built using a Swiss modeler. We identified 35 and 13 nsSNPs in chTLR3 and chTLR4 genes respectively. Sorting Intolerant from Tolerant (SIFT) and Polymorphism Phenotyping v2 (Polyphen-2) analyses, suggested that, out of 35 and 13 nsSNPs, 4 and 2 SNPs were identified to be deleterious in chTLR3 and chTLR4 gene respectively. In chTLR3, 1 deleterious SNP was located in ectodomain and 3 were located in the Toll / IL-1 receptor (TIR) domain. Further structural model of chTLR3-TIR domain suggested that 1 deleterious SNP be present in the B-B loop region, which is important for TIR-TIR domain interactions in the downstream signaling. In chTLR4, the deleterious SNPs were located both in the ectodomain and TIR domain. SNPs predicted for chTLR3 and chTLR4 in this study, might be related to resistance or susceptible to viral infection in chickens. Results from this study will be useful to develop the effective measures in chicken against infectious diseases.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)] - Adzhubei I / 2013 / Predicting functional effect of human missense mutations using PolyPhen 2 / Current Protocols in Human Genetics 76 (1) : 7.20.1 ~ 7.20.41
[학술지(정기간행물)] - Al-Qahtani A / 2012 / Toll-like receptor 3 polymorphism and its association with hepatitis B virus infection in Saudi Arabian patients / Journal of Medical Virology 84 (9) : 1353 ~ 1359
[학술지(정기간행물)] - Botos I / 2011 / The structural biology of Toll-like receptors / Structure 19 (4) : 447 ~ 459
[학술지(정기간행물)] - Cheng J / 2014 / Toll-like receptor 3 inhibits Newcastle disease virus replication through activation of pro-inflammatory cytokines and the type-1 interferon pathway / Archives of Virology 159 (11) : 2937 ~ 2948
[학술지(정기간행물)] - Iwasaki A / 2015 / Control of adaptive immunity by the innate immune system / Nature Immunology 16 (4) : 343 ~
[학술지(정기간행물)] - Al-Qahtani A / 2012 / Toll-like receptor 3 polymorphism and its association with hepatitis B virus infection in Saudi Arabian patients / Journal of Medical Virology 84 (9) : 1353 ~ 1359
[학술지(정기간행물)] - Botos I / 2011 / The structural biology of Toll-like receptors / Structure 19 (4) : 447 ~ 459
[학술지(정기간행물)] - Cheng J / 2014 / Toll-like receptor 3 inhibits Newcastle disease virus replication through activation of pro-inflammatory cytokines and the type-1 interferon pathway / Archives of Virology 159 (11) : 2937 ~ 2948
[학술지(정기간행물)] - Iwasaki A / 2015 / Control of adaptive immunity by the innate immune system / Nature Immunology 16 (4) : 343 ~
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UCI(KEPA) : I410-ECN-0101-2018-527-003597809