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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충남대학교 농업과학연구소 Korean Journal of Agricultural Science Korean Journal of Agricultural Science Vol.45 No.3
- 발행연도
- 2018.9
- 수록면
- 455 - 461 (7page)
이용수
초록· 키워드
오류제보하기
Deoxynivalenol (DON), a Fusarium mycotoxin, causes health hazards for both humans and livestock. Therefore, the aim of this study was to investigate the metabolic profiles of the liver, serum, and urine of piglets fed DON using proton nuclear magnetic resonance (1H NMR) spectroscopy. The 1H-NMR spectra of the liver, serum, and urine samples of the piglets provided with feed containing 8 mg DON/kg for 4 weeks were aligned and identified using the icoshift algorithm of MATLAB R2013b. The data were analyzed by multivariate analysis and by MetaboAnalyst 4.0. The DON-treated groups exhibited discriminating metabolites in the three different sample types. Metabolic profiling by <SUP>1</SUP>H-NMR spectroscopy revealed potential metabolites including lactate, glucose, taurine, alanine, glycine, glutamate, creatine, and glutamine upon mycotoxin exposure (variable importance in the projection, VIP > 1). Forty-six metabolites selected from the principal component analysis (PCA) helped to predict sixty-five pathways in the DON-treated piglets using metabolite sets containing at least two compounds. The DON treatment catalyzed the citrate synthase reactions which led to an increase in the acetate and a decrease in the glucose concentrations. Therefore, our findings suggest that glyceraldehyde-3-phosphate dehydrogenase, citrate synthase, ATP synthase, and pyruvate carboxylase should be considered important in piglets fed DON contaminated feed. Metabolomics analysis could be a powerful method for the discovery of novel indicators underlying mycotoxin treatments.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Conclusion
References
참고문헌 (22)
참고문헌 신청
[학술지(정기간행물)] - Aa JY / 2010 / Differential regulations of blood pressure and perturbed metabolism by total ginsenosides and conventional antihypertensive agents in spontaneously hypertensive rats / Acta Pharmacologica Sinica 31 : 930 ~ 937
[학술지(정기간행물)] - 안준상 / 2017 / 반추동물용 섬유질배합사료(TMR) 제조시설의 사료안전관리 인식 및 사료 중 위해인자의 오염도 조사 / 동물자원연구 28 (1) : 32 ~ 45
[학술지(정기간행물)] - Anukul N / 2013 / Significance of regulation limits in mycotoxin contamination in Asia and risk management programs at the national level / Journal of Food and Drug Analysis 21 : 227 ~ 241
[학술지(정기간행물)] - Brzuzan P / 2015 / MicroRNA expression profiles in liver and colon of sexually immature gilts after exposure to Fusarium mycotoxins / Polish Journal of Veterinary Sciences 18 : 29 ~ 38
[학술지(정기간행물)] - Ji J / 2017 / The antagonistic effect of mycotoxins deoxynivalenol and zearalenone on metabolic profiling in serum and liver of mice / Toxins 9 : 28 ~
[학술지(정기간행물)] - 안준상 / 2017 / 반추동물용 섬유질배합사료(TMR) 제조시설의 사료안전관리 인식 및 사료 중 위해인자의 오염도 조사 / 동물자원연구 28 (1) : 32 ~ 45
[학술지(정기간행물)] - Anukul N / 2013 / Significance of regulation limits in mycotoxin contamination in Asia and risk management programs at the national level / Journal of Food and Drug Analysis 21 : 227 ~ 241
[학술지(정기간행물)] - Brzuzan P / 2015 / MicroRNA expression profiles in liver and colon of sexually immature gilts after exposure to Fusarium mycotoxins / Polish Journal of Veterinary Sciences 18 : 29 ~ 38
[학술지(정기간행물)] - Ji J / 2017 / The antagonistic effect of mycotoxins deoxynivalenol and zearalenone on metabolic profiling in serum and liver of mice / Toxins 9 : 28 ~
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UCI(KEPA) : I410-ECN-0101-2018-520-003591342