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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.10
- 수록면
- 16 - 27 (12page)
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초록· 키워드
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In addition to T cell-dependent (TD) Ab responses, T cells can also regulate T cell-independent (TI) B cell responses in the absence of a specific major histocompatibility complex (MHC) class II and antigenic peptide-based interaction between T and B cells. The elucidation of T cells capable of supporting TI Ab responses is important for understanding the cellular mechanism of different types of TI Ab responses. Natural killer T (NKT) cells represent 1 type of helper T cells involved in TI Ab responses and more candidate helper T cells responsible for TI Ab responses may also include γδ T cells and recently reported B-1 helper CD4<SUP>+</SUP> T cells. Marginal zone (MZ) B and B-1 cells, 2 major innate-like B cell subsets considered to function independently of T cells, interact with innate-like T cells. Whereas MZ B and NKT cells interact mutually for a rapid response to blood-borne infection, peritoneal memory phenotype CD49d<SUP>high</SUP>CD4<SUP>+</SUP> T cells support natural Ab secretion by B-1 cells. Here the role of innate-like T cells in the so-called TI Ab response is discussed. To accommodate the involvement of T cells in the TI Ab responses, we suggest an expanded classification of TD Ab responses that incorporate cognate and non-cognate B cell help by innate-like T cells.
목차
ABSTRACT
INTRODUCTION
INNATE OR INNATE-LIKE LYMPHOCYTES
TD AB RESPONSE
TI AB RESPONSE
INVOLVEMENT OF INNATE OR INNATE-LIKE T CELLS IN TI AB RESPONSE
SUGGESTION OF A NEW SUB-CLASSIFICATION OF TD AB RESPONSES
REFERENCES
참고문헌 (3)
참고문헌 신청
문하나 / 2012 / LPS-Induced Migration of Peritoneal B-1 Cells is Associated with Upregulation of CXCR4 and Increased Migratory Sensitivity to CXCL12 / Journal of Korean Medical Science 27(1):27~35
권동일 / 2017 / Lineage Differentiation Program of Invariant Natural Killer T Cells / Immune Network 17(6):365~377
양정인 / 2017 / Serosal Cavities Contain Two Populations of Innate-like integrin α4highCD4+ T Cells, Integrin α4β1+α6β1+α4β7− and α4β1+α6β1−α4β7+ Cells / Immune Network 17(6):392~401
권동일 / 2017 / Lineage Differentiation Program of Invariant Natural Killer T Cells / Immune Network 17(6):365~377
양정인 / 2017 / Serosal Cavities Contain Two Populations of Innate-like integrin α4highCD4+ T Cells, Integrin α4β1+α6β1+α4β7− and α4β1+α6β1−α4β7+ Cells / Immune Network 17(6):392~401
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UCI(KEPA) : I410-ECN-0101-2019-517-000120579