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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 334 - 340 (7page)
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초록· 키워드
오류제보하기
The cytoplasmic elicitor, nucleotide-binding domain and leucine-rich repeat containing domain receptors (NLRs) is well established molecules in its role in inflammatory response. Among 22 NLR receptors, NOD2 is one of the intensively studied genes of elucidating for the inflammatory bowel disease and Crohn"s disease as well. Recent research have accumulated that common genetic mutations in Parkinson"s disease (PD) are increasingly related to the susceptibility to Crohn"s disease. In this study, with the Korean Genome and Epidemiology Study, we aimed to perform the association between NOD2 polymorphisms and blood cell counts [WBC (white blood cell) count, RBC (red blood cell) count, platelet count], which linked supposedly to cytoplasmic inflammatory responses with clinical specialty. Linear regression analyses were performed, controlling for residential area, sex, and age as covariates. As a results, 12 SNPs from NOD2 gene were significantly associated with WBC counts (Bonferroni correction P-value criteria < 0.05/23=0.00218). In this study, we could ensure an association with NOD2 gene and WBC counts. This is the first report to have relationship between SNPs of NOD2 gene and WBC counts.
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서론
재료 및 방법
결과
고찰
REFERENCES
참고문헌 (27)
참고문헌 신청
[학술지(정기간행물)] - Bergsbaken T / 2009 / Pyroptosis: host cell death and inflammation / Nature Reviews Microbiology 7 : 99 ~
[학술지(정기간행물)] - Branquinho D / 2016 / NOD2 mutations and colorectal cancer - Where do we stand? / World Journal of Gastrointestinal Surgery 8 : 284 ~ 293
[학술지(정기간행물)] - Cho YS / 2009 / A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits / Nature Genetics 41 : 527 ~ 534
[학술지(정기간행물)] - Cooney R / 2010 / NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation / Nature Medicine 16 : 90 ~
[학술지(정기간행물)] - Fujioka S / 2017 / Occurrence of Crohn's disease with Parkinson's disease / Parkinsonism & Related Disorders 37 : 116 ~ 117
[학술지(정기간행물)] - Branquinho D / 2016 / NOD2 mutations and colorectal cancer - Where do we stand? / World Journal of Gastrointestinal Surgery 8 : 284 ~ 293
[학술지(정기간행물)] - Cho YS / 2009 / A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits / Nature Genetics 41 : 527 ~ 534
[학술지(정기간행물)] - Cooney R / 2010 / NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation / Nature Medicine 16 : 90 ~
[학술지(정기간행물)] - Fujioka S / 2017 / Occurrence of Crohn's disease with Parkinson's disease / Parkinsonism & Related Disorders 37 : 116 ~ 117
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UCI(KEPA) : I410-ECN-0101-2019-510-000302838