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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.23 No.4
- 발행연도
- 2018.12
- 수록면
- 309 - 316 (8page)
- DOI
- 10.3746/pnf.2018.23.4.309
이용수
초록· 키워드
오류제보하기
We have previously shown that supplementation of wheat with hot-water extract reduces myocardial injury by inhibiting apoptosis in a rat model of myocardial infarction (MI). Arabinogalactan-peptide (AGP), a cell wall polysaccharide of wheat, was also responsible for the protection. However, the underlying mechanisms were not elucidated. In this study, we investigated the underlying mechanisms for how AGP supplementation reduces myocardial injury. First, we isolated highly pure AGP from all-purpose wheat flour. We supplemented rats with AGP at a dose of 100 mg/kg/d for 3 days, and subjected the rats to ischemia (30 min) through ligation of the left anterior descending coronary artery followed by reperfusion (3 h) through a release of the ligation. Supplementation with AGP significantly reduced the infarct size in the heart. In addition, AGP intake inhibited the apoptotic cascade, determined through decreased mitogen-activated protein kinases (p38 and c-Jun N-terminal kinase) phosphorylation, decreased Bcl-2-associated X protein/B-cell lymphoma ratios, and decreased generation of nicked DNA, which was confirmed through western blotting and terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling staining. These findings indicate that AGP intake can protect against myocardial injury. Traditionally, consumption of dietary fiber such as AGP has been shown to reduce MI risk by inhibiting preocclusion steps through reducing risk factors. Our findings suggest that AGP intake can also reduce MI risk by inhibiting postocclusion steps. This study describes a better dietary recommendation and new prevention strategy for reducing MI risk through regular consumption of wheat rich in AGP.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (25)
참고문헌 신청
[학술지(정기간행물)] - Sanchis-Gomar F / 2016 / Epidemiology of coronary heart disease and acute coronary syndrome / Ann Transl Med 4 : 256 ~
[학술지(정기간행물)] - Tuso P / 2015 / A plant-based diet, atherogenesis, and coronary artery disease prevention / Perm J 19 : 62 ~ 67
[학술지(정기간행물)] - Swirski FK / 2013 / Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure / Science 339 : 161 ~ 166
[학술지(정기간행물)] - Kim MY / 2014 / Intake of hot water-extracted apple protects against myocardial injury by inhibiting apoptosis in an ischemia/reperfusion rat model / Nutr Res 34 : 951 ~ 960
[학술지(정기간행물)] - Lim SH / 2017 / Xyloglucan intake attenuates myocardial injury by inhibiting apoptosis and improving energy metabolism in a rat model of myocardial infarction / Nutr Res 45 : 19 ~ 29
[학술지(정기간행물)] - Tuso P / 2015 / A plant-based diet, atherogenesis, and coronary artery disease prevention / Perm J 19 : 62 ~ 67
[학술지(정기간행물)] - Swirski FK / 2013 / Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure / Science 339 : 161 ~ 166
[학술지(정기간행물)] - Kim MY / 2014 / Intake of hot water-extracted apple protects against myocardial injury by inhibiting apoptosis in an ischemia/reperfusion rat model / Nutr Res 34 : 951 ~ 960
[학술지(정기간행물)] - Lim SH / 2017 / Xyloglucan intake attenuates myocardial injury by inhibiting apoptosis and improving energy metabolism in a rat model of myocardial infarction / Nutr Res 45 : 19 ~ 29
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UCI(KEPA) : I410-ECN-0101-2019-594-000300583