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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.23 No.4
- 발행연도
- 2018.12
- 수록면
- 374 - 381 (8page)
- DOI
- 10.3746/pnf.2018.23.4.374
이용수
초록· 키워드
오류제보하기
Rumex crispus (Rc) and Cordyceps militaris (Cm) mixture (Rc-Cm; AST2017-01) ameliorated production of proinflammatory cytokines, inflammation-related genes, and nitric oxide (NO) induced by lipopolysaccharide (LPS) in mouse splenocytes. Rc-Cm (6:4) and Taemyeongcheong (commercial healthy drink containing Rc-Cm) were co-administered along with LPS. Rc-Cm inhibited production of tumor necrosis factor α, interferon γ, interleukin (IL)-1β, and IL-6 in LPSinduced splenocytes. However, levels of inflammatory cytokines were elevated in the absence of LPS treatment. Rc-Cm significantly suppressed mRNA expression of IL-1β, IL-6, and the inflammation-related genes inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2), as well as NO production upon LPS co-treatment. Whereas Rc-Cm increased mRNA expression of IL-1β, and IL-6, but did not up-regulate expression of iNOS and COX-2, or increase NO production without LPS co-treatment. Therefore, treatment of Rc-Cm to LPS-induced splenocytes ameliorated induction of pro-inflammatory cytokines, inflammation-related genes, and NO production. In the absence of LPS, Rc-Cm treatment up-regulated pro-inflammatory cytokines but did not alter expression of the inflammation-related genes iNOS and COX-2 or NO production. These results indicate that the natural phytochemicals chrysophanol and cordycepin in Rc-Cm promote antiinflammatory activities and immune cell responses.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (38)
참고문헌 신청
[학술지(정기간행물)] - Hotamisligil GS / 2007 / Inflammation, metaflammation and immunometabolic disorders / Nature 542 : 177 ~ 185
[학술지(정기간행물)] - Gioannini TL / 2007 / Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells / Immunol Res 39 : 249 ~ 260
[학술지(정기간행물)] - Poltorak A / 1998 / Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice : mutations in Tlr4 gene / Science 282 : 2085 ~ 2088
[학술지(정기간행물)] - Lu YC / 2008 / LPS/TLR4 signal transduction pathway / Cytokine 42 : 145 ~ 151
[학술지(정기간행물)] - Xie QW / 1994 / Role of transcription factor NF-B/Rel in induction of nitric oxide synthase / J Biol Chem 269 : 4705 ~ 4708
[학술지(정기간행물)] - Gioannini TL / 2007 / Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells / Immunol Res 39 : 249 ~ 260
[학술지(정기간행물)] - Poltorak A / 1998 / Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice : mutations in Tlr4 gene / Science 282 : 2085 ~ 2088
[학술지(정기간행물)] - Lu YC / 2008 / LPS/TLR4 signal transduction pathway / Cytokine 42 : 145 ~ 151
[학술지(정기간행물)] - Xie QW / 1994 / Role of transcription factor NF-B/Rel in induction of nitric oxide synthase / J Biol Chem 269 : 4705 ~ 4708
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UCI(KEPA) : I410-ECN-0101-2019-594-000300503