지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Hyperlipidemia is defined as conditions of the accumulation of lipids such as free fatty acids (FFA), triglyceride (TG), cholesterol and/or phospholipid in the bloodstream. Hyperlipidemia can cause lipid accumulation in non-adipose tissue, which is lipid-cytotoxic effects in many tissues and mediates cell dysfunction, inflammation or programmed cell death (PCD). TG is considered to be a major cause of atherosclerosis through inflammatory necrosis of vascular endothelial cells. Recently, TG have also been shown to exhibit lipid-cytotoxicity and induce PCD. Therefore, we investigated the effect of TG on the cytotoxic effect of various cell types. When exposed to TG, the cell viability of U937 monocytes and Jurkat T lymphocytes, as well as the cell viability of MCF-7, a non-immune cell, decreased in time- and dose-dependent manner. In U937 cells and Jurkat cells, caspase-9, an intrinsic apoptotic caspase, and caspase-8, an extrinsic apoptotic caspase, were increased by exposure to TG. However, in TG-treated MCF-7 cells, caspase-8 activity increased only without caspase-9 activity. In addition, the reduction of cell viability by TG was recovered when all three cell lines were treated with pan-caspase inhibitor. These results suggest that activation of apoptotic caspases by TG causes lipotoxic effect and decreases cell viability.
목차
서론
재료 및 방법
결과
고찰
REFERENCES
참고문헌 (29)
참고문헌 신청
Aflaki E / 2011 / Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages / J Biol Chem 286:7418~7428
Aronis A / 2005 / Mechanism underlying oxidative stress-mediated lipotoxicity: Exposure of j774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis / Free Radic Biol Med 38:1221~1230
Aronis A / 2008 / Lipotoxic effects of triacylglycerols in j774.2 macrophages / Nutrition 24:167~176
Bosma M / 2014 / Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity / Biochim Biophys Acta 1841:1648~1655
Carmena R / 2004 / Atherogenic lipoprotein particles in atherosclerosis / Circulation 109:III2~III7
Aronis A / 2005 / Mechanism underlying oxidative stress-mediated lipotoxicity: Exposure of j774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis / Free Radic Biol Med 38:1221~1230
Aronis A / 2008 / Lipotoxic effects of triacylglycerols in j774.2 macrophages / Nutrition 24:167~176
Bosma M / 2014 / Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity / Biochim Biophys Acta 1841:1648~1655
Carmena R / 2004 / Atherogenic lipoprotein particles in atherosclerosis / Circulation 109:III2~III7
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Evaluation Expression of the Caspase-3 and Caspase-9 Apoptotic Genes in Schizophrenia Patients
Clinical Psychopharmacology and Neuroscience
2023 .02
-
Inducible Nitric Oxide Synthase Mediates the Triglyceride-induced Death of THP-1 Monocytes
대한의생명과학회지
2023 .06
-
Hep88 mAb-Mediated Paraptosis-Like Apoptosis in HepG2 Cells via Downstream Upregulation and Activation of Caspase-3, Caspase-8 and Caspase-9
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
잔디 예지물의 생리활성 탐색
생약학회지(Korean Journal of Pharmacognosy)
2015 .09
-
The evaluation of biocides on the eye irritation based on OECD TG 491 and TG 492
환경독성보건학회 심포지엄 및 학술대회
2018 .06
-
Anti-leukemic properties of deferasirox via apoptosis in murine leukemia cell lines
Blood Research
2015 .01
-
Over Expression of BCL2 and Low Expression of Caspase 8 Related to TRAIL Resistance in Brain Cancer Stem Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Upregulation of TNF-α by Triglycerides is Mediated by MEK1 Activation in Jurkat T Cells
대한의생명과학회지
2018 .09
-
Induction of Human Hepatocellular Carcinoma HepG2 Cell Apoptosis by Naringin
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Phytochemicals from Goniothalamus griffithii Induce Human Cancer Cell Apoptosis
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Effect of caspases and RANKL induced by heavy force in orthodontic root resorption
대한치과교정학회지
2018 .07
-
Apoptotic Effects of 6-Gingerol in Human Breast Cancer Cells
International Journal of Oral Biology
2015 .01
-
Triglyceride-Rich Lipoproteins and Novel Targets for Anti-atherosclerotic Therapy
Korean Circulation Journal
2018 .01
-
Triglyceride Regulates the Expression of M1 and M2 Macrophage-specific Markers in THP-1 Monocytes
대한의생명과학회지
2016 .12
-
MiR-484 Protects Rat Myocardial Cells from Ischemia-Reperfusion Injury by Inhibiting Caspase-3 and Caspase-9 during Apoptosis
Korean Circulation Journal
2020 .01
-
Inhibition of cell growth and induction of apoptosis by acacetin in FaDu human pharyngeal carcinoma cells
International Journal of Oral Biology
2020 .01
-
Heat stress during summer increases Caspase-3 activation in the ovary of domestic sow
한국가축위생학회지
2024 .09
-
Quercetin exerts preferential cytotoxic effects on malignant mesothelioma cells by inducing p53 expression, caspase-3 activation, and apoptosis
대한직업환경의학회 학술대회 논문집
2015 .11
-
Cell viability analysis
대한견주관절의학회 학술대회논문집
2015 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2019-510-000546412