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논문 기본 정보

자료유형
학술저널
저자정보
김민선 (선문대학교) 임지성 (선문대학교) 박태진 (선문대학교) 고광욱 (대호양행) 김승영 (선문대학교)
저널정보
한국생물공학회 KSBB Journal KSBB Journal Vol.34 No.1(Wn.168)
발행연도
2019.3
수록면
31 - 37 (7page)
DOI
10.7841/ksbbj.2019.34.1.31

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초록· 키워드

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In this study, antioxidation and anti-inflammatory activity Agaricus Brazei (AC) extract were examined. Antioxidation activity was increased as the concentration of AC extract increased (Concentration-dependant manner). The contents of phenolic compounds and flavonoids were 111.3019 mg/g and 15.473 mg/g, respectively. In anti-inflammatory effect test using AC extract, no toxicity was shown. NO production was inhibited in range of 50 to 100 μg/mL of AC extract as concentration dependant manner. PGE₂ and Proinflammatory cytokines IL-6 production was decreased as concentration dependant manner. However, TNF-α production was not changed compare to control. iNOS and COX-2 expression, representative factors of signal transduction of inflammatory effects, were decreased as dose-dependant manner. These result indicates that AC extract is involved in regulatory pathway of iNOS, which is related to NO, and COX-2, which is related to PGE₂. As a result, AC extract is useful material which has anti-oxidant effect and anti-inflammatory effect with no toxicity.

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Abstract
1. INTRODUCTION
2. MATERIALS AND METHOD
3. RESULTS
4. CONCLUSION
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UCI(KEPA) : I410-ECN-0101-2019-470-000569107