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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.4
- 수록면
- 109 - 116 (8page)
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초록· 키워드
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The HWND_G02 (Salvia miltiorrhiza Bunge, Crataegus pinnatifida, Polygonum multiflorum Thunberg, Cnidium officinale Makino) and HWND_G03 (Cinnamonum cassia Blume, Salvia miltiorrhiza Bunge, Crataegus pinnatifida, Polygonum multiflorum Thunberg, Cnidium officinale Makino, Allium macrostemon Bunge) are new natural mixture composed with several oriental herbs. The aim of the present study was to investigate the effects of HWND extracts on high cholesterol diet (HCD)-induced hyperlipidemic rats. Male Sprague-Dawley rats were divided into five groups: control, HCD, atorvastatin (5 ㎎/㎏, po), ethanolic extracts of HWND_G02 (1,000 ㎎/㎏, po) and HWND_G03 (1,000 ㎎/㎏, po) were administered to the HCD-induced hyperlipidemic rats for 4 weeks to evaluate their anti-hyperlipidemic activities. HWND extracts markedly decreased body and liver wight gain, and recovered serum lipid levels, such as total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) in the HCDinduced hyperlipidemic rats. Furthermore, the lipid levels (TC and TG) and the lipid accumulation were significantly lowered in the liver tissue of HWND-administrated rats. After a HCD, each group had a lower atherogenic index (AI) compared to the HCD group. In conclusion, these data suggest that HWND extracts could be the candidate for the material to prevent hyperlipidemia.
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참고문헌 (41)
참고문헌 신청
Abliz A / 2014 / Effect of Cydonia oblonga Mill. leaf extract on serum lipids and liver function in a rat model of hyperlipidaemia / Journal of Ethnopharmacology 151:970~974
Boullart AC / 2012 / Serum triglycerides and risk of cardiovascular disease / Biochimica et Biophysica Acta 1821:867~875
Babelova A / 2013 / Antiatherosclerotic mechanisms of statin therapy / Current Opinion in Pharmacology 13:260~264
Chait A / 1990 / Acquired hyperlipidemia(secondary dyslipoproteinemias) / Endocrinology Metabolism Clinics North America 19:259~278
Chen K / 2011 / Vav guanine nucleotide exchange factors link hyperlipidemia and a prothrombotic state / Blood 117:5744~5750
Boullart AC / 2012 / Serum triglycerides and risk of cardiovascular disease / Biochimica et Biophysica Acta 1821:867~875
Babelova A / 2013 / Antiatherosclerotic mechanisms of statin therapy / Current Opinion in Pharmacology 13:260~264
Chait A / 1990 / Acquired hyperlipidemia(secondary dyslipoproteinemias) / Endocrinology Metabolism Clinics North America 19:259~278
Chen K / 2011 / Vav guanine nucleotide exchange factors link hyperlipidemia and a prothrombotic state / Blood 117:5744~5750
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UCI(KEPA) : I410-ECN-0101-2019-480-000586373