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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.11
- 수록면
- 103 - 111 (9page)
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This study was performed to investigate the cytoprotective effects of Stachys riederi var. japonica ethanol extract (SREE) to control oxidative stress induced by UVA-irradiation by examining antioxidant capacity and gene expression of cytochrome c using human dermal fibroblasts. The total polyphenolics and flavonoids in the SREE were 41.2 and 25.4 mg/g, respectively. At concentrations of 500 and 1000 μg/mL, the electron-donating ability of SREE was 48.6% and 82.0%, respectively, and the 2,2"-azino-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity was 62.3% and 78.8%, respectively. These findings showed that SREE has a fairly good antioxidant capacity. As determined by an MTT assay, the maximum permissible level for treating SREE to human dermal fibroblasts was shown to be over 200 μg/mL. SREE (200 μg/mL) significantly decreased cytochrome c mRNA and protein expression by 31.1% (p<0.001) and 38.8% (p<0.01), respectively. These findings suggest that SREE may protect human skin cells against mitochondrial-dependent apoptosis. Therefore, SREE seems to be a natural antioxidant to protect cells against oxidative stress induced by UVA-irradiation.
목차
ABSTRACT
Introduction
Materials and Methods
Results and Discussion
Discussion
References
참고문헌 (39)
참고문헌 신청
Krutmann J / 2000 / Ultraviolet A radiation-induced biological effects in human skin: relevance for photoaging and photodermatosis / J Dermatol Sci 23(Suppl. 1):S22~S26
Varani J / 2000 / Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin / J Invest Dermatol 114:480~486
Seo MY / 2009 / Anti-aging effect of rice wine in cultured human fibroblasts and keratinocytes / J Biosci Bioeng 107:266~271
Peterson CM / 2012 / Skeletal muscle mitochondria and aging: a review / J Aging Res :1~20
Maverakis E / 2010 / Light, including ultraviolet / J Autoimmun 34:J247~J257
Varani J / 2000 / Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin / J Invest Dermatol 114:480~486
Seo MY / 2009 / Anti-aging effect of rice wine in cultured human fibroblasts and keratinocytes / J Biosci Bioeng 107:266~271
Peterson CM / 2012 / Skeletal muscle mitochondria and aging: a review / J Aging Res :1~20
Maverakis E / 2010 / Light, including ultraviolet / J Autoimmun 34:J247~J257
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UCI(KEPA) : I410-ECN-0101-2019-047-000802375