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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제4호
- 발행연도
- 2019.1
- 수록면
- 518 - 526 (9page)
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Pueraria montana var. lobata is a bioactive substance with various beneficial health effects and has long been extensively used as a traditional medication for the treatment of fever, acute dysentery, diabetes, and cardiovascular diseases in Northeast Asian countries. The purpose of this study was to evaluate the cytoprotective activity of Pueraria montana var. lobata ethanol extract (PLE) for ultraviolet B (UVB)-induced oxidative stress in human dermal fibroblasts (HDF). It was hypothesized that PLE treatment (25-100 μg/ml) would reduce intracellular reactive oxygen species (ROS) levels as well as increase collagen production in UVB-irradiated HDF. The results confirmed this theory, with collagen production increasing in the PLE treatment group in a dose-dependent manner. In addition, regulators of cellular ROS accumulation, including HO-1 and NOQ-1, were activated by Nrf2, which was mediated by PLE. Hence, intracellular levels of ROS were also reduced in the PLE treatment group in a dose-dependent manner. In conclusion, PLE increases collagen production and maintains hyaluronic acid (HA) levels in human dermal fibroblasts exposed to UVB-irradiation, thereby inhibiting photoaging.
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참고문헌 (21)
참고문헌 신청
Baumann L / 2007 / Skin ageing and its treatment / J. Pathol 211:241~251
Debacq-Chainiaux F / 2012 / UV, stress and aging / Dermatoendocrinol 4:236~240
Makrantonaki E / 2012 / Genetics and skin aging / Dermatoendocrinol 4:280~284
Wlaschek M / 2001 / Solar UV irradiation and dermal photoaging / J. Photochem. Photobiol. B 63:41~51
Ma W / 2001 / Chronological ageing and photoageing of the fibroblasts and the dermal connective tissue / Clin. Exp. Dermatol 26:592~599
Debacq-Chainiaux F / 2012 / UV, stress and aging / Dermatoendocrinol 4:236~240
Makrantonaki E / 2012 / Genetics and skin aging / Dermatoendocrinol 4:280~284
Wlaschek M / 2001 / Solar UV irradiation and dermal photoaging / J. Photochem. Photobiol. B 63:41~51
Ma W / 2001 / Chronological ageing and photoageing of the fibroblasts and the dermal connective tissue / Clin. Exp. Dermatol 26:592~599
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