지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.6
- 수록면
- 91 - 102 (12page)
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초록· 키워드
오류제보하기
Ovarian cancer (OC), the deadliest gynecological cancer, results in poor overall survival, urgently requiring a novel therapeutic approach. As cumulative exposures to endotoxins decreased OC risk epidemiologically, we evaluated if LPS, a Toll-like receptor 4 agonist known as active component of endotoxins, could increase survival in the murine peritoneal dissemination model of SKOV-3 OC cells. LPS significantly increased the mean survival time of more than 116 days compared with 63 days in the control. Furthermore, no tumor burden was present in three mice among eight LPS-treated mice. SKOV-3 cells were not responsive to LPS and showed unaltered chemokine signature. Rather than direct effects to OC cells, LPS was found to increase proinflammatory chemokines and cytokines, such as CXCL1, CXCL8, TNF, and IL-1B, in innate immune system. Taken together, LPS is likely to potentiate the cytotoxic-related innate immunogenicity via proinflammatory chemokines and cytokines, which attenuates the peritoneal dissemination of OC.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (48)
참고문헌 신청
Torre LA / 2018 / Ovarian cancer statistics, 2018 / CA Cancer J Clin 68:284~296
Doubeni CA / 2016 / Diagnosis and management of ovarian cancer / Am Fam Physician 93:937~944
Siegel RL / 2018 / Cancer statistics, 2018 / CA Cancer J Clin 68:7~30
Rojas V / 2016 / Molecular characterization of epithelial ovarian cancer: implications for diagnosis and treatment / Int J Mol Sci 17:E2113
Kurman RJ / 2016 / The dualistic model of ovarian carcinogenesis: revisited, revised, and expanded / Am J Pathol 186:733~747
Doubeni CA / 2016 / Diagnosis and management of ovarian cancer / Am Fam Physician 93:937~944
Siegel RL / 2018 / Cancer statistics, 2018 / CA Cancer J Clin 68:7~30
Rojas V / 2016 / Molecular characterization of epithelial ovarian cancer: implications for diagnosis and treatment / Int J Mol Sci 17:E2113
Kurman RJ / 2016 / The dualistic model of ovarian carcinogenesis: revisited, revised, and expanded / Am J Pathol 186:733~747
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UCI(KEPA) : I410-ECN-0101-2019-517-000788608