지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 541 - 548 (8page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaBipolar disorder (BD) is a debilitating psychiatric disease with unknown etiology. Recent studies have shown inflammation as a potential contributing factor of BD pathogenesis. However, potential associations between chemokine and chemokine receptor polymorphisms and BD have been fundamentally understudied. To identify participation of chemokines in BD pathogenesis, we examined genetic variants of several chemokine and chemokine receptor genes.
MethodsaaThe study population comprised 200 patients with BD and 195 age- and sex-matched healthy controls. Genotyping of monocyte chemotactic protein 1 (MCP-1) A2518G, CCR2 V64I, CCR5 Δ32, CCR5 A55029G, stromal cell-derived factor 1 (SDF-1) 3’A, and CXCR4 C138T polymorphisms was performed using polymerase chain reaction and restriction enzyme digestion.
ResultsaaWe found that CCR5-Δ32 II and CXCR4-C138T C+ genotype frequencies contributed to an increased risk for BD. However, no statistical significance could be obtained with these genotypes after Bonferroni correction. A significant asssociation was only found with MCP-1 GG and G+ genotypes, which were markedly more prevalent in patients with BD and these genotypes seemed to significantly increase the risk for BD even after Bonferroni correction.
ConclusionaaOur findings indicate an association between genetic variants of certain chemokine and chemokine receptor (especially MCP-1) genes and BD. The exact mechanisms by which these variants contribute to BD pathogenesis and their clinical implications need to be further investigated.
목차
등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Stuart MJ / 2014 / Chemokines and chemokine receptors in mood disorders, schizophrenia, and cognitive impairment: a systematic review of biomarker studies / Neurosci Biobehav Rev 42:93~115
Hamdani N / 2013 / Immunity, inflammation, and bipolar disorder: diagnostic and therapeutic implications / Curr Psychiatry Rep 15:387
Pae CU / 2004 / Monocyte chemoattractant protein-1(MCP1)promoter-2518 polymorphism may confer a susceptibility to major depressive disorder in the Korean population / Psychiatry Res 127:279~281
Roh MS / 2007 / No association of the MCP-1 promoter A-2518G polymorphism with bipolar disorder in the Korean population / Neurosci Lett 427:1~5
Pae CU / 2004 / Monocyte chemoattractant protein-1 promoter-2518 polymorphism may have an influence on clinical heterogeneity of bipolar I disorder in the Korean population / Neuropsychobiology 49:111~114
Hamdani N / 2013 / Immunity, inflammation, and bipolar disorder: diagnostic and therapeutic implications / Curr Psychiatry Rep 15:387
Pae CU / 2004 / Monocyte chemoattractant protein-1(MCP1)promoter-2518 polymorphism may confer a susceptibility to major depressive disorder in the Korean population / Psychiatry Res 127:279~281
Roh MS / 2007 / No association of the MCP-1 promoter A-2518G polymorphism with bipolar disorder in the Korean population / Neurosci Lett 427:1~5
Pae CU / 2004 / Monocyte chemoattractant protein-1 promoter-2518 polymorphism may have an influence on clinical heterogeneity of bipolar I disorder in the Korean population / Neuropsychobiology 49:111~114
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