지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.6
- 수록면
- 196 - 200 (5page)
이용수
초록· 키워드
오류제보하기
Effect of retinoids, i.e., all-trans retinoic acid and 13-cis retinoic acid, on the activity of nitric oxide synthase (NOS) was evaluated in human malignant keratinocytes to examine the possible correlation of retinoids with NOS activities. All-trans retinoic acid and 13-cis retinoic acid did not alter the nitric oxide (NO) production. However, in the presence of lipopolysaccharide (LPS, 1 ㎍/mL), they significantly increased NO release in a dose-dependent manner until 48 h at concentrations of 50~100 μM. The degree of upregulation of NO by all-trans retinoic acid and 13-cis retinoic acid increased up to 35% and 37%, respectively, compared to that by the control, which demonstrated the upregulation of LPS-inducible nitric oxide synthase (iNOS)-dependent generation of NO as well as showing a crucial link between retinoids-induced activity and NOS. Findings of this study now suggest that the upregulation of LPS-iNOS activity may be associated with modulation of retinoids-induced control of cellular developmental processes, which may produce new therapeutics of retinoids in the complexity of how NO affects human keratinocytes.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Altucci L / 2001 / The promise of retinoids to fight against cancer / Nature Reviews Cancer 1:181~193
Aranda E / 2012 / Nitric oxide and cancer: the emerging role of S nitrosylation / Current Molecular Medicine 11:50~67
Beckenbach L / 2015 / Retinoid treatment of skin diseases / European Journal of Dermatology 5:384~391
Bécherel PA / 1997 / Inducible nitric oxide synthase and proinflammatory cytokine expression by human keratinocytes during acute urticaria / Molecular Medicine 3:686~694
Bécherel PA / 1995 / Interleukin-10 inhibits IgE-mediated nitric oxide synthase induction and cytokine synthesis in normal human keratinocytes / European Journal of Immunology 25:2992~2995
Aranda E / 2012 / Nitric oxide and cancer: the emerging role of S nitrosylation / Current Molecular Medicine 11:50~67
Beckenbach L / 2015 / Retinoid treatment of skin diseases / European Journal of Dermatology 5:384~391
Bécherel PA / 1997 / Inducible nitric oxide synthase and proinflammatory cytokine expression by human keratinocytes during acute urticaria / Molecular Medicine 3:686~694
Bécherel PA / 1995 / Interleukin-10 inhibits IgE-mediated nitric oxide synthase induction and cytokine synthesis in normal human keratinocytes / European Journal of Immunology 25:2992~2995
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Inhibitory Effect of Retinoids on Alkaline Phosphatase Isoenzymes Activity in Human Serum
대한의생명과학회지
2017 .09
-
Identification of proteins differentially expressed by retinoic acid in an ischemic cerebral cortex animal model
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Identification of regulated by retinoic acid treatment in cerebral ischemic injury - A proteomics approach
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Retinoic acid alleviates the reduction of the ubiquitin-proteasome system due to ischemic brain injury
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Retinoic acid regulates thioredoxin and peroxiredoxin-2 in ischemic-injured cerebral cortex
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Neuroprotective effects of retinoic acid in middle cerebral artery occlusion model by regulating apoptotic cell death
한국실험동물학회 학술발표대회 논문집
2021 .07
-
The Effects of Retinoic Acid and MAPK Inhibitors on Phosphorylation of Smad2/3 Induced by Transforming Growth Factor β1
Tuberculosis and Respiratory Diseases
2019 .01
-
Elevated Cellular Retinoic Acid Binding Protein-I in Cerebrospinal Fluid of Patients with Hemorrhagic Cerebrovascular Diseases : Preliminary Study
대한신경외과학회지
2015 .01
-
레티노익산이 접목된 폴리아미노산 유도체의 자기조립 현상
대한화장품학회지
2016 .01
-
Comparison of the Effects of 13-cis Retinoic Acid and Melatonin on the Viabilities of SH-SY5Y Neuroblastoma Cell Line
대한신경외과학회지
2015 .01
-
피부과에서의 레티노이드의 사용
대한의사협회지
2022 .05
-
Anti-inflammatory Effects of Ethanol Extract of Chinese Medicinal Plants in Yanjin on LPS-stimulated RAW 264.7 Macrophages
대한본초학회지(본초분과학회지)
2018 .01
-
Adverse Pregnancy and Child Outcomes in Oral Retinoid-Exposed Pregnancies: A Nationwide Population-Based Study
Journal of Korean Medical Science
2024 .07
-
Suppression of nitric oxide (NO) production by traditional medicine
셀메드
2018 .05
-
Integrative Omics Reveals Metabolic and Transcriptomic Alteration of Nonalcoholic Fatty Liver Disease in Catalase Knockout Mice
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Inhibitory Effect of a Sesquiterpene from Artemisia iwayomogi on Expression of Inducible Nitric Oxide Synthase by Suppression of I-κBα Degradation in LPS-stimulated RAW 264.7 Cells
Natural Product Sciences
2017 .06
-
Anti-inflammatory Effects of Aster yomena Extracts by the Suppression of Inducible Nitric Oxide Synthase Expression
대한의생명과학회지
2017 .06
-
Control of Innate and Adaptive Lymphocytes by the RAR-Retinoic Acid Axis
Immune Network
2018 .02
-
Pathological Lesions and Inducible Nitric Oxide Synthase Expressions in the Liver of Mice Experimentally Infected with Clonorchis sinensis
Parasites, Hosts and Diseases
2015 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2019-510-000875032