Molecular and Morphological Evidence of Hepatotoxicity after Silver Nanoparticle Exposure: A Systematic Review, In Silico, and Ultrastructure Investigation

Kanidta Sooklert; Asarn Wongjarupong; Sarocha Cherdchom; Nicha Wongjarupong; Depicha Jindatip; Yupa Phungnoi; Rojrit Rojanathanes; Amornpun Sereemaspun

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자료유형: 학술저널

저자정보: Kanidta Sooklert (Chulalongkorn University) Asarn Wongjarupong (Queen SavangVadhana Memorial Hospital) Sarocha Cherdchom (Chulalongkorn University) Nicha Wongjarupong (Chulalongkorn University) Depicha Jindatip (Chulalongkorn University) Yupa Phungnoi (Nakhon Ratchasima Rajabhat University) Rojrit Rojanathanes (Chulalongkorn University) Amornpun Sereemaspun (Chulalongkorn University)

저널정보: 한국독성학회 Toxicological Research Toxicological Research Vol.35 No.3

발행연도: 2019.7

수록면: 257 - 270 (14page)

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연구배경

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Silver nanoparticles (AgNPs) have been widely used in a variety of applications in innovative development; consequently, people are more exposed to this particle. Growing concern about toxicity from AgNP exposure has attracted greater attention, while questions about nanosilver-responsive genes and consequences for human health remain unanswered. By considering early detection and prevention of nanotoxicology at the genetic level, this study aimed to identify 1) changes in gene expression levels that could be potential indicators for AgNP toxicity and 2) morphological phenotypes correlating to toxicity of HepG2 cells. To detect possible nanosilver-responsive genes in xenogenic targeted organs, a comprehensive systematic literature review of changes in gene expression in HepG2 cells after AgNP exposure and in silico method, connection up- and down-regulation expression analysis of microarrays (CU-DREAM), were performed. In addition, cells were extracted and processed for transmission electron microscopy to examine ultrastructural alterations. From the Gene Expression Omnibus (GEO) Series database, we selected genes that were up- and down-regulated in AgNPs, but not up- and down-regulated in silver ion exposed cells, as nanosilver-responsive genes. HepG2 cells in the AgNP-treated group showed distinct ultrastructural alterations. Our results suggested potential representative gene data after AgNPs exposure provide insight into assessment and prediction of toxicity from nanosilver exposure.

#Silver nanoparticles #Ultrastructural alterations #Silver-nanoparticle responsive gene #Systematic review

참고문헌 (40)

참고문헌 신청

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Griffin, S. / 2017 / Natural nanoparticles: a particular matter inspired by nature / Antioxidants (Basel) 7:E3

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Rai, M. / 2017 / Recent advances in use of silver nanoparticles as antimalarial agents / Int. J. Pharm 526:254~270

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