Low-frequency ultrasound increase effectiveness of silver nanoparticles in a purulent wound model

Myronov Petro; Bugaiov Volodymyr; Holubnycha Viktoriia; Sikora Vladyslav; Deineka Volodymyr; Lyndin Mykola; Opanasyuk Anatoliy; Romaniuk Anatoliy; Pogorielov Maksym

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자료유형: 학술저널

저자정보: Myronov Petro (Sumy State University) Bugaiov Volodymyr (Sumy State University) Holubnycha Viktoriia (Sumy State University) Sikora Vladyslav (Sumy State University) Deineka Volodymyr (Sumy State University) Lyndin Mykola (Sumy State University) Opanasyuk Anatoliy (Sumy State University) Romaniuk Anatoliy (Sumy State University) Pogorielov Maksym (Sumy State University)

저널정보: 대한의용생체공학회 Biomedical Engineering Letters (BMEL) Biomedical Engineering Letters (BMEL) Vol.10 No.4

발행연도: 2020.1

수록면: 621 - 631 (11page)

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Bacterial biofilm formation and antibiotic resistance are the main factors of surgical wound complications. Traditional treatments in some cases cannot provide complete bacterial eradication and new therapeutic approaches should be developed to overcome antibiotic resistance. Silver nanoparticles (AgNPs) can be the first choice for bacteria treatment but their clinical application is limited due to toxic effects. Combination of AgNPs with the low-frequency ultrasound (US) treatment expected to decrease toxicity and leads to the facilitation of wound healing. In current research we investigated the antibacterial activity of AgNPs per se and in combination with low-frequency US, assessed the cytotoxicity of AgNPs on human dermal fibroblasts and finally, wound healing was evaluated in purulent wound model (96 white laboratory rats) applying AgNPs and US as a treatment strategy. Our results demonstrate no toxic effect of AgNPs in minimum inhibitory concentrations and show increasing their antibacterial effectiveness after US application. The combination of low-frequency US and AgNPs provides reduction of the inflammatory reaction, microorganism elimination and leads to facilitation of new tissue formation with complete epithelization. All effects were significant over the Chlorhexidine treatment, monotherapy with AgNPs or US. Advanced effectiveness of complex therapy opens new perspectives for clinical application of AgNPs solution accompanied by US.

#Silver nanoparticles Ultrasound Purulent wounds Antibacterial activity Cytotoxicity

참고문헌 (32)

참고문헌 신청

Merkow RP / 2015 / Underlying reasons associated with hospital readmission following surgery in the United States / JAMA 313(5):483~495

Liu R / 2020 / Emergency medical services care and sepsis trajectories / Prehosp Emerg Care 23:1~8

Roy R / 2018 / Strategies for combating bacterial biofilms : A focus on anti-biofilm agents and their mechanisms of action / Virulence 9(1):522~554

Patini R / 2020 / The effect of different antibiotic regimens on bacterial resistance: a systematic review / Antibiotics (Basel) 9(1):E22

Flemming HC / 2010 / The biofilm matrix / Nat Rev Microbiol 8(9):623~633

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