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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background: The presence of skin problems in patients using external lower limb prosthesis is recurrent. This has generated the need to develop interfaces for prosthesis with the ability to control microbial growth. Silver nanoparticles (AgNPs) have been implemented in the development of biomaterials because of their high antimicrobial activity. This article discusses the development of an AgNP-containing polymer composite with antimicrobial activity for developing prosthetic liners. Methods: AgNPs were synthesized using a photochemical method and certain physicochemical properties were characterized. Furthermore, the antimicrobial activity of AgNPs against Staphylococcus aureus ATCC 25923 and methicillin-resistant Staphylococcus aureus (MRSA), was assessed on the basis of their minimum inhibitory concentrations (MICs). AgNPs were incorporated into a silicon elastomer to assess certain physicomechanical properties, antimicrobial activity and cytotoxic effect of the material. Results: Themaximum antimicrobial activity of the material against Staphylococcus aureus ATCC 25923 andMRSA was 41.58% ±2.97% at AgNP concentration of 32.98 μg/mL and 14.85% ±5.94% at AgNP concentration of 16.49 μg/mL, respectively. Additionally, the material exhibited tensile yield strength, rupture tensile strength, and tensile modulus of elasticity of 0.70 - 1.10 MPa, 0.71?1.06 MPa, and 0.20 - 0.30 MPa, respectively. The mechanical characteristics of the material were within the acceptable range for use in external lower limb prosthetic and orthotic interfaces. Conclusions: It was possible to incorporate the AgNPs in a silicone elastomer, finding that the composite developed presented antimicrobial activity against Staphylococcus aureus ATCC 25923 and MRSA when compared to non-AgNP material samples.
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참고문헌 (83)
참고문헌 신청
International Organization for Standardization / 1989 / ISO 8549-1:1989Prosthetics and orthotics – Vocabulary – Part 1: General terms for external limb prostheses and external orthoses / Technical Committee : ISO/TC 168Prosthetics and orthotics
E. C. T. Baars / 2016 / Literature review of the possible advantages of silicon liner socket use in trans-tibial prostheses / Prosthetics and Orthotics International 29(1):27~37
Dillingham TR / 2001 / Use and satisfaction with prosthetic devices among persons with trauma-related amputations. A long-term outcome study / Am J Phys Med Rehabil 80(8):563~571
Kamiar Ghoseiri / 2014 / Prevalence of heat and perspiration discomfort inside prostheses: Literature review / Journal of Rehabilitation Research and Development 51(6):855~868
Kenji Hachisuka / 2001 / Hygiene problems of residual limb and silicone liners in transtibial amputees wearing the total surface bearing socket / Archives of Physical Medicine and Rehabilitation 82(9):1286~1290
E. C. T. Baars / 2016 / Literature review of the possible advantages of silicon liner socket use in trans-tibial prostheses / Prosthetics and Orthotics International 29(1):27~37
Dillingham TR / 2001 / Use and satisfaction with prosthetic devices among persons with trauma-related amputations. A long-term outcome study / Am J Phys Med Rehabil 80(8):563~571
Kamiar Ghoseiri / 2014 / Prevalence of heat and perspiration discomfort inside prostheses: Literature review / Journal of Rehabilitation Research and Development 51(6):855~868
Kenji Hachisuka / 2001 / Hygiene problems of residual limb and silicone liners in transtibial amputees wearing the total surface bearing socket / Archives of Physical Medicine and Rehabilitation 82(9):1286~1290
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