지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 781 - 788 (8page)
이용수
초록· 키워드
오류제보하기
Background/Aims: Although proton pump inhibitors (PPIs) have been widely used for the prevention and treatment of stress gastric ulcers in hospital settings, there are concerns that PPIs increase the risk of Clostridium difficile infection (CDI). However, little is known about the risk of CDI following PPI and histamine-2 receptor antagonist (H2RA) use. We evaluated the comparative hospital-acquired CDI occurrence risk associated with the concurrent use of PPIs versus H2RAs. Methods: A systematic search of PubMed, MEDLINE/Ovid, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science, and Google Scholar through August 19, 2016, identified 12 studies that reported the hospital-acquired CDI occurrence following H2RA and PPI use for the prevention and treatment of stress gastric ulcers. Random-effects pooled odds ratios and 95% confidence intervals were estimated. Heterogeneity was measured using I2, and a meta-regression analysis was conducted. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was used to assess the overall quality of the evidence. Results: A total of 74,132 patients from 12 observational studies were analyzed. Compared to H2RAs, PPIs increased the risk of CDI by 38.6% (pooled odds ratio, 1.386; 95% confidence interval, 1.152 to 1.668; p=0.001; I2=42.81%). Subgroup analyses of the purpose of study medication use, study site, and study design confirmed the consistency of a greater CDI risk with PPIs than with H2RAs. The overall quality of evidence was rated as low. Conclusions: The use of PPIs for both the prevention and treatment of stress ulcers was associated with a 38.6% increased risk of hospital-acquired CDI occurrence compared to H2RA use.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Aseeri M / 2008 / Gastric acid suppression by proton pump inhibitors as a risk factor for clostridium difficile-associated diarrhea in hospitalized patients / Am J Gastroent
Barletta JF / 2013 / Proton pump inhibitors and the risk for hospital-acquired Clostridium difficile infection / Mayo Clin Proc 88 : 1085 ~ 1090
Barletta JF / 2014 / Proton pump inhibitors increase the risk for hospital-acquired Clostridium difficile infection in critically ill patients / Crit Care 18 : 714 ~
Bartlett JG / 1978 / Role of Clostridium difficile in antibiotic-associated pseudomembranous colitis / Gastroenterology 75 : 778 ~ 782
Deshpande A / 2012 / Association between proton pump inhibitor therapy and Clostridium difficile infection in a meta-analys
Barletta JF / 2013 / Proton pump inhibitors and the risk for hospital-acquired Clostridium difficile infection / Mayo Clin Proc 88 : 1085 ~ 1090
Barletta JF / 2014 / Proton pump inhibitors increase the risk for hospital-acquired Clostridium difficile infection in critically ill patients / Crit Care 18 : 714 ~
Bartlett JG / 1978 / Role of Clostridium difficile in antibiotic-associated pseudomembranous colitis / Gastroenterology 75 : 778 ~ 782
Deshpande A / 2012 / Association between proton pump inhibitor therapy and Clostridium difficile infection in a meta-analys
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Risk of Clostridium difficile Infection with the Use of a Proton Pump Inhibitor for Stress Ulcer Prophylaxis in Critically Ill Patients
Gut and Liver
2016 .01
-
Does Proton Pump Inhibitor Increase the Clostridium difficile Infection Risk in the Treatment and Prophylaxis of Stress Ulcers than Histanime-2 Receptor Antagonist?
Gut and Liver
2017 .01
-
중환자에서 스트레스성 궤양 예방 약물에 따른 감염성 합병증 발생률 비교
한국임상약학회지
2016 .01
-
Proton Pump Inhibitors Should be Used with Caution in Critically Ill Patients to Prevent the Risk of Clostridium difficile Infection
Gut and Liver
2016 .01
-
Histamine-2 Receptor Antagonists and Proton Pump Inhibitors Are Associated With Reduced Risk of SARS-CoV-2 Infection Without Comorbidities Including Diabetes, Hypertension, and Dyslipidemia: A Propensity Score-Matched Nationwide Cohort Study
Journal of Korean Medical Science
2023 .04
-
Limited Effect of Rebamipide in Addition to Proton Pump Inhibitor (PPI) in the Treatment of Post-Endoscopic Submucosal Dissection Gastric Ulcers: A Randomized Controlled Trial Comparing PPI Plus Rebamipide Combination Therapy with PPI Monotherapy
Gut and Liver
2016 .01
-
25 Years of Proton Pump Inhibitors: A Comprehensive Review
Gut and Liver
2017 .01
-
Advantages and Disadvantages of Long-term Proton Pump Inhibitor Use
Journal of Neurogastroenterology and Motility (JNM)
2018 .01
-
노인층에서 Clostridium difficile 감염 약물사용평가 및 비호전군에 대한 영향인자
한국임상약학회지
2018 .01
-
Adverse Effects Associated with Long-Term Use of Proton Pump Inhibitors
전남의대학술지
2023 .05
-
Detection and characterization of Clostridium difficile infections tracking the trends of Clostridium difficile culture
한국의료질향상학회지
2016 .01
-
Clinical and Microbiological Risk Factors for Community-Associated Clostridioides difficile Infections
Annals of Clinical Microbiology
2022 .06
-
Vonoprazan Versus Intravenous Proton Pump Inhibitor for Prevention of High-Risk Peptic Ulcers Rebleeding After Endoscopic Hemostasis
Korean Journal of Helicobacter Upper Gastrointestinal Research
2024 .09
-
Risk of Pyogenic Liver Abscess in Proton Pump Inhibitor Users: New Inventory of Proton Pump Inhibitor Induced Complications?
Journal of Neurogastroenterology and Motility (JNM)
2021 .10
-
Fecal Calprotectin Level Reflects the Severity of Clostridium difficile Infection
Annals of Laboratory Medicine
2017 .01
-
요양병원 입원 환자의 욕창 발생 및 영향요인: 인지기능 저하 대상자
기본간호학회지
2022 .05
-
신장이식 환자에게 위장관계 증상 예방 목적으로 투여하는 Proton Pump Inhibitors (PPIs) 안전성 비교분석
병원약사회지
2020 .01
-
스트레스성 위장궤양 예방치료제 처방남용에 대한 의료전문가의 인식과 지식 분석
한국임상약학회지
2015 .01
-
Diagnostic and Treatment Approaches for Refractory Peptic Ulcers
Clinical Endoscopy
2015 .01
-
Incidence of Clostridioides difficile Infections in Republic of Korea: A Prospective Study With Active Surveillance vs. National Data From Health Insurance Review & Assessment Service
Journal of Korean Medical Science
2024 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0