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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 917 - 924 (8page)
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초록· 키워드
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Background/Aims: The ability of endoscopic submucosal dissection (ESD) to resect large early gastric cancers (EGCs) results in the need to treat large artificial gastric ulcers.
This study assessed whether the combination therapy of rebamipide plus a proton pump inhibitor (PPI) offered benefits over PPI monotherapy. Methods: In this prospective, randomized, multicenter, open-label, and comparative study, patients who had undergone ESD for EGC or gastric adenoma were randomized into groups receiving either rabeprazole monotherapy (10 mg/day, n=64) or a combination of rabeprazole plus rebamipide (300 mg/day, n=66). The Scar stage (S stage) ratio after treatment was compared, and factors independently associated with ulcer healing were identified by using multivariate analyses. Results: The S stage rates at 4 and 8 weeks were similar in the two groups, even in the subgroups of patients with large amounts of tissue resected and regardless of CYP2C19 genotype. Independent factors for ulcer healing were circumferential location of the tumor and resected tissue size; the type of treatment did not affect ulcer healing. Conclusions: Combination therapy with rebamipide and PPI had limited benefits compared with PPI monotherapy in the treatment of post-ESD gastric ulcer (UMIN Clinical Trials Registry, UMIN000007435).
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Gotoda T / 2007 / Endoscopic resection of early gastric cancer / Gastric Cancer 10:1~11
Oda I / 2006 / A multicenter retrospective study of endoscopic resection for early gastric cancer / Gastric Cancer 9:262~270
Gotoda T / 2006 / Endoscopic submucosal dissection of early gastric cancer / J Gastroenterol 41:929~942
Uedo N / 2007 / Effect of a proton pump inhibitor or an H2-receptor antagonist on prevention of bleeding from ulcer after endoscopic submucosal dissection of early gastric cancer: a prospective randomized controlled trial / Am J Gastroenterol 102:1610~1616
Oh TH / 2009 / Degree of healing and healingassociated factors of endoscopic submucosal dissection-induced ulcers after pantoprazole therapy for 4 weeks / Dig Dis Sci 54:1494~1499
Oda I / 2006 / A multicenter retrospective study of endoscopic resection for early gastric cancer / Gastric Cancer 9:262~270
Gotoda T / 2006 / Endoscopic submucosal dissection of early gastric cancer / J Gastroenterol 41:929~942
Uedo N / 2007 / Effect of a proton pump inhibitor or an H2-receptor antagonist on prevention of bleeding from ulcer after endoscopic submucosal dissection of early gastric cancer: a prospective randomized controlled trial / Am J Gastroenterol 102:1610~1616
Oh TH / 2009 / Degree of healing and healingassociated factors of endoscopic submucosal dissection-induced ulcers after pantoprazole therapy for 4 weeks / Dig Dis Sci 54:1494~1499
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