지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 27 - 36 (10page)
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초록· 키워드
오류제보하기
Drug-induced liver injury (DILI) remains a significant clinical challenge and is the leading cause of acute liver failure in most countries. An aging population that uses more medications, a constant influx of newly developed drugs and a growing risk from unfamiliar herbal and dietary supplements will make DILI an increasing part of clinical practice. Currently, the most effective strategy for disease management is rapid identification, withholding the inciting agents, supportive care and having a firm understanding of the expected natural history. There are resources available to aid the clinician, including a new online “textbook” as well as causality assessment tools, but a heightened awareness of risk and the disease’s varying phenotypes and good history-taking remain cornerstones to diagnosis. Looking ahead, growing registries of cases, pharmacoepidemiology studies and translational research into the mechanisms of injury may produce better diagnostic tools, markers for risk and disease, and prevention and therapeutics.
목차
등록된 정보가 없습니다.
참고문헌 (107)
참고문헌 신청
Ostapowicz G / 2002 / Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States / Ann Intern Med 137:947~954
Wilke RA / 2007 / Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges / Nat Rev Drug Discov 6:904~916
Björnsson ES / 2014 / Epidemiology and risk factors for idiosyncratic drug-induced liver injury / Semin Liver Dis 34:115~122
Sgro C / 2002 / Incidence of drug-induced hepatic injuries: a French population-based study / Hepatology 36:451~455
de Abajo FJ / 2004 / Acute and clinically relevant drug-induced liver injury: a population based case-control study / Br J Clin Pharmacol 58:71~80
Wilke RA / 2007 / Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges / Nat Rev Drug Discov 6:904~916
Björnsson ES / 2014 / Epidemiology and risk factors for idiosyncratic drug-induced liver injury / Semin Liver Dis 34:115~122
Sgro C / 2002 / Incidence of drug-induced hepatic injuries: a French population-based study / Hepatology 36:451~455
de Abajo FJ / 2004 / Acute and clinically relevant drug-induced liver injury: a population based case-control study / Br J Clin Pharmacol 58:71~80
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