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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 272 - 275 (4page)
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초록· 키워드
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Iodine-131 is a radioisotope that is routinely used for the treatment of differentiated thyroid cancer after total or near-total thyroidectomy. However, there is some evidence that iodine-131 can induce liver injury . Here we report a rare case of drug-induced liver injury (DILI) caused by iodine-131 in a patient with regional lymph node metastasis after total thyroidectomy. A 47-year-old woman was admitted with elevated liver enzymes and symptoms of general weakness and nausea. Ten weeks earlier she had undergone a total thyroidectomy for papillary thyroid carcinoma and had subsequently been prescribed levothyroxine to reduce the level of thyroid-stimulating hormone. Eight weeks after surgery she underwent iodine-131 ablative therapy at a dose of 100 millicuries, and subsequently presented with acute hepatitis after 10 days. To rule out all possible causative factors, abdominal ultrasonography, endoscopic ultrasonography (on the biliary tree and gall bladder), and a liver biopsy were performed. DILI caused by iodine-131 was suspected. Oral prednisolone was started at 30 mg/day, to which the patient responded well.
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Mayson SE / 2015 / The evolving use of radioiodine therapy in differentiated thyroid cancer / Oncology 88:247~256
Bonnema SJ / 2012 / Radioiodine therapy in benign thyroid diseases: effects, side effects, and factors affecting therapeutic outcome / Endocr Rev 33:920~980
Doi SA / 2007 / Ablation of the thyroid remnant and I-131 dose in differentiated thyroid cancer: a metaanalysis revisited / Clin Med Res 5:87~90
Lin R / 2015 / I-131 remnant ablation after thyroidectomy induced hepatotoxicity in a case of thyroid cancer / BMC Gastroenterol 15:56
Jhummon NP / 2013 / Iodine-131 induced hepatotoxicity in previously healthy patients with Grave’s disease / Thyroid Res 6:4
Bonnema SJ / 2012 / Radioiodine therapy in benign thyroid diseases: effects, side effects, and factors affecting therapeutic outcome / Endocr Rev 33:920~980
Doi SA / 2007 / Ablation of the thyroid remnant and I-131 dose in differentiated thyroid cancer: a metaanalysis revisited / Clin Med Res 5:87~90
Lin R / 2015 / I-131 remnant ablation after thyroidectomy induced hepatotoxicity in a case of thyroid cancer / BMC Gastroenterol 15:56
Jhummon NP / 2013 / Iodine-131 induced hepatotoxicity in previously healthy patients with Grave’s disease / Thyroid Res 6:4
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