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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 601 - 606 (6page)
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초록· 키워드
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Background/Aims: In patients with corticosteroid-refractory ulcerative colitis (UC), cyclosporine or infliximab may be added to the treatment regimen to induce remission. Here, we aimed to compare the efficacy of cyclosporine and infliximab. Methods: Between January 1995 and May 2012, the medical records of 43 patients with corticosteroid-refractory UC who received either infliximab or cyclosporine as a rescue therapy at a tertiary care hospital in Korea were reviewed. Results: Among the 43 patients, 10 underwent rescue therapy with cyclosporine and the remaining 33 patients received infliximab. A follow-up of 12 months was completed for all patients. The colectomy rate at 12 months was 30% and 3% in the cyclosporine and the infliximab groups, respectively (p=0.034). However, the Cox proportional hazard model indicated that the treatment of rescue therapy was not an independent associate factor for preventing colectomy (p=0.164). In the subgroup analysis, infliximab with azathioprine was superior to cyclosporine for preventing colectomy (hazard ratio of infliximab with azathioprine compared with cyclosporine only, 0.073; 95% confidence interval, 0.008 to 0.629). Conclusions: No difference between infliximab and cyclosporine with respect to preventing colectomy was noted. However, infliximab with azathioprine may be more effective than cyclosporine alone for preventing colectomy.
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등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Lee HJ / 2012 / Long-term clinical outcomes and factors predictive of relapse after 5-aminosalicylate or sulfasalazine therapy in patients with mild-to-moderate ulcerative colitis / Hepatogastroenterology 59:1415~1420
정고은 / 2006 / 스테로이드 저항 중증 궤양성 대장염 환자에서 스테로이드와 Cyclosporin A의 병합 투여와 스테로이드 단독 연장 투여의 치료 효과 비교 / 대한소화기학회지 48(4):263~268
Cohen RD / 1999 / Intravenous cyclosporin in ulcerative colitis: a five-year experience / Am J Gastroenterol 94:1587~1592
Ogata H / 2006 / A randomised dose finding study of oral tacrolimus (FK506) therapy in refractory ulcerative colitis / Gut 55:1255~1262
Baumgart DC / 2006 / Tacrolimus is safe and effective in patients with severe steroid-refractory or steroid-dependent inflammatory bowel disease: a long-term follow-up / Am J Gastroenterol 101:1048~1056
정고은 / 2006 / 스테로이드 저항 중증 궤양성 대장염 환자에서 스테로이드와 Cyclosporin A의 병합 투여와 스테로이드 단독 연장 투여의 치료 효과 비교 / 대한소화기학회지 48(4):263~268
Cohen RD / 1999 / Intravenous cyclosporin in ulcerative colitis: a five-year experience / Am J Gastroenterol 94:1587~1592
Ogata H / 2006 / A randomised dose finding study of oral tacrolimus (FK506) therapy in refractory ulcerative colitis / Gut 55:1255~1262
Baumgart DC / 2006 / Tacrolimus is safe and effective in patients with severe steroid-refractory or steroid-dependent inflammatory bowel disease: a long-term follow-up / Am J Gastroenterol 101:1048~1056
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