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논문 기본 정보

자료유형
학술저널
저자정보
Bae June Hwa (Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea) Park Jung-Bin (Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea) Baek Ji Eun (Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea) Hong Seung Wook (Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Park Sang Hyoung (Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaInflammatory Bowel Disease Center, Asan Medical Center, University of Ulsan College) Yang Dong-Hoon (Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea) Ye Byong Duk (Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaInflammatory Bowel Disease Center, Asan Medical Center, University of Ulsan College) Byeon Jeong-Sik (Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea) Myung Seung-Jae (Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea) Yang Suk-Kyun (Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaInflammatory Bowel Disease Center, Asan Medical Center, University of Ulsan College) Hwang Sung Wook (Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaInflammatory Bowel Disease Center, Asan Medical Center, University of Ulsan College)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver Vol.18 No.4
발행연도
2024.7
수록면
667 - 676 (10page)
DOI
10.5009/gnl230291

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초록· 키워드

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Background/Aims: Studies on elective switching to the subcutaneous (SC) formulation of infliximab revealed comparable efficacy and safety and higher infliximab level than those exhibited by intravenous (IV) infliximab. However, no studies have reported on the effectiveness of SC switching in ulcerative colitis (UC) patients who experienced IV infliximab failure during maintenance treatment. Methods: This retrospective study included UC patients who had been switched to SC infliximab because of IV infliximab failure, between January 2021 and January 2023. Group A was defined as having clinically and biochemically active UC (secondary loss of response), and group B consisted of patients with stable symptoms but biochemically active UC. Results: Twenty-three patients met the inclusion criteria: 15 in group A and eight in group B. The serum infliximab levels significantly increased after SC switching in both groups. The electively switched group also exhibited increased infliximab levels after SC switching. Patients in group A showed improved partial Mayo score with a significant decrease in fecal calprotectin and C-reactive protein after switching. In group B, the fecal calprotectin level significantly decreased without clinical relapse after switching. A high proportion of patients (≥80%) in both groups achieved clinical and/or biochemical responses at the last follow-up. During the follow-up period, only two patients in group A discontinued SC infliximab, and only one complained of severe injection site reaction. Conclusions: In UC patients who experience IV infliximab failure during maintenance treatment, switching to SC infliximab may be a promising option because of better efficacy and safety.
#Ulcerative colitis #Infliximab #Subcutaneous

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