지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Cerebral amyloid angiopathy (CAA) involves cerebrovascular amyloid deposition and is classified into several types according to the amyloid protein involved. Of these, sporadic amyloid β-protein (Aβ)-type CAA is most commonly found in older individuals and in patients with Alzheimer’s disease (AD). Cerebrovascular Aβ deposits accompany functional and pathological changes in cerebral blood vessels (CAA-associated vasculopathies). CAA-associated vasculopathies lead to development of hemorrhagic lesions [lobar intracerebral macrohemorrhage, cortical microhemorrhage, and cortical superficial siderosis (cSS)/focal convexity subarachnoid hemorrhage (SAH)], ischemic lesions (cortical infarction and ischemic changes of the white matter), and encephalopathies that include subacute leukoencephalopathy caused by CAA-associated inflammation/angiitis. Thus, CAA is related to dementia, stroke, and encephalopathies. Recent advances in diagnostic procedures, particularly neuroimaging, have enabled us to establish a clinical diagnosis of CAA without brain biopsies. Sensitive magnetic resonance imaging (MRI) methods, such as gradient-echo T2* imaging and susceptibility-weighted imaging, are useful for detecting cortical microhemorrhages and cSS. Amyloid imaging with amyloid-binding positron emission tomography (PET) ligands, such as Pittsburgh Compound B, can detect CAA, although they cannot discriminate vascular from parenchymal amyloid deposits. In addition, cerebrospinal fluid markers may be useful, including levels of Aβ40 for CAA and anti-Aβ antibody for CAA-related inflammation. Moreover, cSS is closely associated with transient focal neurological episodes (TFNE). CAA-related inflammation/angiitis shares pathophysiology with amyloid-related imaging abnormalities (ARIA) induced by Aβ immunotherapies in AD patients. This article reviews CAA and CAA-related disorders with respect to their epidemiology, pathology, pathophysiology, clinical features, biomarkers, diagnosis, treatment, risk factors, and future perspectives.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Bejot Y / 2013 / Intracerebral haemorrhage profiles are changing: results from the Dijon population-based study / Brain 136 : 658 ~ 664
Hirohata M / 2010 / Clinical features of non-hypertensive lobar intracerebral hemorrhage related to cerebral amyloid angiopathy / Eur J Neurol 17 : 823 ~ 829
Itoh Y / 1993 / Cerebral amyloid angiopathy: a significant cause of cerebellar as well as lobar cerebral hemorrhage in the elderly / J Neurol Sci 116 : 135 ~ 141
Maeda A / 1993 / Computer-assisted three-dimensional image analysis of cerebral amyloid angiopathy / Stroke 24 : 1857 ~ 1864
Mandybur TI / 1986 / Cerebral amyloid angiopathy : the vascular pathology and complications / J Neuropathol Exp Neurol 45 : 79 ~ 90
Hirohata M / 2010 / Clinical features of non-hypertensive lobar intracerebral hemorrhage related to cerebral amyloid angiopathy / Eur J Neurol 17 : 823 ~ 829
Itoh Y / 1993 / Cerebral amyloid angiopathy: a significant cause of cerebellar as well as lobar cerebral hemorrhage in the elderly / J Neurol Sci 116 : 135 ~ 141
Maeda A / 1993 / Computer-assisted three-dimensional image analysis of cerebral amyloid angiopathy / Stroke 24 : 1857 ~ 1864
Mandybur TI / 1986 / Cerebral amyloid angiopathy : the vascular pathology and complications / J Neuropathol Exp Neurol 45 : 79 ~ 90
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Cerebral Amyloid Angiopathy: An Undeniable Small Vessel Disease
대한뇌졸중학회지
2024 .01
-
Multimodal Imaging Findings of Cerebral Amyloid Angiopathy Related Inflammation With Unusual Clinical Manifestation: A Case Report
Investigative Magnetic Resonance Imaging
2023 .03
-
Cerebral Amyloid Angiopathy Presenting as Cerebral Infarction in a Young Man: A Case Report
Investigative Magnetic Resonance Imaging
2022 .09
-
Inflammatory Cerebral Amyloid Angiopathy: A Broad Clinical Spectrum
Journal of Clinical Neurology
2023 .05
-
Congenital Analbuminemia in a Korean Male Diagnosed with Single Nucleotide Polymorphism in the ALB Gene: The First Case Reported in Korea
Yonsei Medical Journal
2019 .01
-
Pseudotumoral Presentation of Cerebral Amyloid-Beta Angiopathy: Case Report and Review of Literature
PSYCHIATRY INVESTIGATION
2021 .01
-
Prevalence of Cerebral Amyloid Angiopathy Pathology and Strictly Lobar Microbleeds in East-Asian Versus Western Populations: A Systematic Review and Meta-Analysis
대한뇌졸중학회지
2024 .05
-
Coronary Artery Aneurysm after Second-Generation Drug-Eluting Stent Implantation
Yonsei Medical Journal
2019 .01
-
Pathologically Confirmed Cerebral Amyloid Angiopathy with No Radiological Sign in a Patient with Early Onset Alzheimer’s Disease
Yonsei Medical Journal
2018 .01
-
Iron deficiency anemia as a predictor of coronary artery abnormalities in Kawasaki disease
Clinical and Experimental Pediatrics
2019 .01
-
Decreased Basal Ganglia Volume in Cerebral Amyloid Angiopathy
대한뇌졸중학회지
2021 .01
-
Clinical Neuropathological Analysis of 10 Cases of Cerebral Amyloid Angiopathy-Related Cerebral Lobar Hemorrhage
대한신경외과학회지
2015 .01
-
Endoscopic Thyroidectomy Via the Cervico-axillary Approach for Thyroid Cancer: Initial Experience in a Single Institute
The Journal of Endocrine Surgery
2017 .01
-
Late Coronary Aneurysm Formation after Kawasaki Disease: a Review of Mechanistic and Clinical Aspects
Korean Circulation Journal
2021 .10
-
Sex-Specific Susceptibility Loci Associated With Coronary Artery Aneurysms in Patients With Kawasaki Disease
Korean Circulation Journal
2024 .09
-
Giant Coronary Artery Aneurysm with Thrombosis Complicated in a Patient with Idiopathic Hypereosinophilic Syndrome
Yonsei Medical Journal
2023 .02
-
Congenital Analbuminemia in Unrelated Algerian and Turkish Families is Caused by the Same Molecular Defect in the Albumin Gene
Annals of Laboratory Medicine
2018 .01
-
Epidemiology, Risk Factors, and Clinical Features of Intracerebral Hemorrhage: An Update
대한뇌졸중학회지
2017 .01
-
A child with Kawasaki disease and genetic warfarin sensitivity from CYP2C9 and VKORC1 gene variants
대한소아응급의학회지
2020 .01
-
Amyloid Depositions and Small Vessel Disease in Patients with Cerebral Amyloid Angiopathy: a Case Series
Dementia and Neurocognitive Disorders(대한치매학회지)
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0