지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background and Purpose Interventions to reduce the risk for cerebrovascular events (CVE; stroke and transient ischemic attack [TIA]) after radiotherapy (RT) for head and neck cancer (HNCA) are needed. Among broad populations, statins reduce CVEs; however, whether statins reduce CVEs after RT for HNCA is unclear. Therefore, we aimed to test whether incidental statin use at the time of RT is associated with a lower rate of CVEs after RT for HNCA. Methods From an institutional database we identified all consecutive subjects treated with neck RT from 2002 to 2012 for HNCA. Data collection and event adjudication was performed by blinded teams. The primary outcome was a composite of ischemic stroke and TIA. The secondary outcome was ischemic stroke. The association between statin use and events was determined using Cox proportional hazard models after adjustment for traditional and RT-specific risk factors. Results The final cohort consisted of 1,011 patients (59±13 years, 30% female, 44% hypertension) with 288 (28%) on statins. Over a median follow-up of 3.4 years (interquartile range, 0.1 to 14) there were 102 CVEs (89 ischemic strokes and 13 TIAs) with 17 in statin users versus 85 in nonstatins users. In a multivariable model containing known predictors of CVE, statins were associated with a reduction in the combination of stroke and TIA (hazard ratio [HR], 0.4; 95% confidence interval [CI], 0.2 to 0.8; P=0.01) and ischemic stroke alone (HR, 0.4; 95% CI, 0.2 to 0.8; P=0.01). Conclusions Incidental statin use at the time of RT for HNCA is associated with a lower risk of stroke or TIA.
목차
등록된 정보가 없습니다.
참고문헌 (45)
참고문헌 신청
Jemal A / 2011 / Global cancer statistics / CA Cancer J Clin 61:69~90
Fletcher GH / 1970 / Radiotherapeutic management of surgical recurrences and postoperative residuals in tumors of the head and neck / Radiology 95:185~188
Snow GB / 1982 / Prognostic factors of neck node metastasis / Clin Otolaryngol Allied Sci 7:185~192
Kramer S / 1987 / Combined radiation therapy and surgery in the management of advanced head and neck cancer: final report of study 73-03 of the Radiation Therapy Oncology Group / Head Neck Surg 10:19~30
Bernier J / 2004 / Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer / N Engl J Med 350:1945~1952
Fletcher GH / 1970 / Radiotherapeutic management of surgical recurrences and postoperative residuals in tumors of the head and neck / Radiology 95:185~188
Snow GB / 1982 / Prognostic factors of neck node metastasis / Clin Otolaryngol Allied Sci 7:185~192
Kramer S / 1987 / Combined radiation therapy and surgery in the management of advanced head and neck cancer: final report of study 73-03 of the Radiation Therapy Oncology Group / Head Neck Surg 10:19~30
Bernier J / 2004 / Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer / N Engl J Med 350:1945~1952
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Statin and the Risk of Ischemic Stroke or Transient Ischemic Attack in Head and Neck Cancer Patients with Radiotherapy
대한뇌졸중학회지
2018 .01
-
Statins in Acute Ischemic Stroke: A Systematic Review
대한뇌졸중학회지
2015 .01
-
Prevention of Intra-Abdominal Adhesions Using the Combination of Mixed Solid of Poloxamer, Gelatin and Chitosan (Mediclore®) and a Statin
대한외과학회 학술대회 초록집
2021 .05
-
급성기 뇌경색 환자에서 Staitn 처방과 임상결과 지표 분석
병원약사회지
2018 .01
-
Combination of Statin and Ezetimibe versus Statin Monotherapy on Cardiovascular Disease and Type 2 Diabetes Incidence among Adults with Impaired Fasting Glucose: a Propensity- Matched Nationwide Cohort Study
지질·동맥경화학회지
2021 .09
-
Effect and Safety of Rosuvastatin in Acute Ischemic Stroke
대한뇌졸중학회지
2016 .01
-
스타틴과 당뇨병 발생 위험
대한의사협회지
2017 .01
-
Low-Density Lipoprotein Cholesterol Level, Statin Use and Myocardial Infarction Risk in Young Adults
지질·동맥경화학회지
2022 .09
-
Impact of Statin Treatment Intensity after Endovascular Revascularization on Lower Extremity Peripheral Artery Disease
Yonsei Medical Journal
2022 .04
-
Effects of Statins for Primary Prevention in the Elderly: Recent Evidence
지질·동맥경화학회지
2020 .01
-
Intensity of Statin Treatment in Korean Patients with Acute Myocardial Infarction and Very Low LDL Cholesterol
지질·동맥경화학회지
2019 .01
-
Statin Supply and Polydrug Use in Older Adults: A Focus on Drug Combinations that Reduce Bone Density
Annals of geriatric medicine and research
2021 .12
-
The Relationship between Delirium and Statin Use According to Disease Severity in Patients in the Intensive Care Unit
Clinical Psychopharmacology and Neuroscience
2023 .02
-
Comparison of Statin With Ezetimibe Combination Therapy Versus Statin Monotherapy for Primary Prevention in Middle-Aged Adults
Korean Circulation Journal
2024 .09
-
Statin Intolerance: an Overview of the Current Status and Possible Treatment Options
지질·동맥경화학회지
2018 .01
-
Clinical Characteristics of Patients With Statin Discontinuation in Korea: A Nationwide Population-Based Study
지질·동맥경화학회지
2024 .01
-
Device Closure or Antithrombotic Therapy After Cryptogenic Stroke in Elderly Patients With a High-Risk Patent Foramen Ovale
대한뇌졸중학회지
2024 .05
-
Trends in Incident and Recurrent Rates of First-Ever Ischemic Stroke in Taiwan between 2000 and 2011
대한뇌졸중학회지
2016 .01
-
Myocardial Infarction, Stroke, and All-Cause Mortality according to Low-Density Lipoprotein Cholesterol Level in the Elderly, a Nationwide Study
Diabetes and Metabolism Journal
2022 .09
-
Statin and Ezetimibe Combination Therapy Decreases Mean Platelet Volume Compared to Statin Monotherapy
대한뇌졸중학회지
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0