지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background and Purpose The benefit of statins in acute stroke remains uncertain. Statins may prevent stroke recurrence during the acute stage of stroke via pleiotropic effects. However, statins may increase the risk of intracerebral hemorrhage. We investigated the effect and safety of rosuvastatin in acute stroke patients.
Methods This randomized, double-blind, multi-center trial compared rosuvastatin 20 mg and placebo in statin-naïve stroke patients who underwent diffusion-weighted imaging (DWI) within 48 hours after symptom onset. The primary outcome was occurrence of new ischemic lesions on DWI at 5 or 14 days.
Results This trial was stopped early after randomization of 316 patients due to slow enrollment. Among 289 patients with at least one follow-up imaging, the frequency of new ischemic lesions on DWI was not different between groups (rosuvastatin: 27/137, 19.7% vs. placebo: 36/152, 23.6%) (relative risk 0.83, 95% confidence interval 0.53–1.30). Infarct volume growth at 5 days (log-transformed volume change, rosuvastatin: 0.2±1.0 mm3 vs. placebo: 0.3±1.3 mm3; P=0.784) was not different, either. However, hemorrhagic infarction or parenchymal/subarachnoid hemorrhage on gradient-recalled echo magnetic resonance imaging occurred less frequently in the rosuvastatin group (6/137, 4.4%) than the placebo group (22/152, 14.5%, P=0.007). Among 314 patients with at least one dose of study medication, progression or clinical recurrence of stroke tended to occur less frequently in the rosuvastatin group (1/155, 0.6% vs. 7/159, 4.4%, P=0.067). Adverse events did not differ between groups.
Conclusions The efficacy of rosuvastatin in reducing recurrence in acute stroke was inconclusive. However, statin use was safe and reduced hemorrhagic transformation.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Baigent C / 2005 / Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins / Lancet 366:1267~1278
Amarenco P / 2006 / High-dose atorvastatin after stroke or transient ischemic attack / N Engl J Med 355:549~559
Tziomalos K / 2015 / Comparative effects of more versus less aggressive treatment with statins on the long-term outcome of patients with acute ischemic stroke / Atherosclerosis 243:65~70
Bourcier T / 2000 / HMG CoA reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells / Arterioscler Thromb Vasc Biol 20:556~562
Schäfer A / 2005 / Rosuvastatin reduces platelet activation in heart failure : role of NO bioavailability / Arterioscler Thromb Vasc Biol 25:1071~1077
Amarenco P / 2006 / High-dose atorvastatin after stroke or transient ischemic attack / N Engl J Med 355:549~559
Tziomalos K / 2015 / Comparative effects of more versus less aggressive treatment with statins on the long-term outcome of patients with acute ischemic stroke / Atherosclerosis 243:65~70
Bourcier T / 2000 / HMG CoA reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells / Arterioscler Thromb Vasc Biol 20:556~562
Schäfer A / 2005 / Rosuvastatin reduces platelet activation in heart failure : role of NO bioavailability / Arterioscler Thromb Vasc Biol 25:1071~1077
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Statins in Acute Ischemic Stroke: A Systematic Review
대한뇌졸중학회지
2015 .01
-
A Case of Statin-Induced Interstitial Pneumonitis due to Rosuvastatin
Tuberculosis and Respiratory Diseases
2015 .01
-
Comparison between Atorvastatin and Rosuvastatin in Renal Function Decline among Patients with Diabetes
Endocrinology and Metabolism
2017 .01
-
Moderate-Intensity Rosuvastatin Plus Ezetimibe Versus High-Intensity Rosuvastatin for Target Low-Density Lipoprotein Cholesterol Goal Achievement in Patients With Recent Ischemic Stroke: A Randomized Controlled Trial
대한뇌졸중학회지
2023 .05
-
Incidental Statin Use and the Risk of Stroke or Transient Ischemic Attack after Radiotherapy for Head and Neck Cancer
대한뇌졸중학회지
2018 .01
-
급성기 뇌경색 환자에서 Staitn 처방과 임상결과 지표 분석
병원약사회지
2018 .01
-
Rhabdomyolysis-induced acute kidney injury requiring hemodialysis in a patient on long-term, moderate-intensity rosuvastatin: a case report and literature review
Medical Biological Science and Engineering
2024 .01
-
Prevention of Intra-Abdominal Adhesions Using the Combination of Mixed Solid of Poloxamer, Gelatin and Chitosan (Mediclore®) and a Statin
대한외과학회 학술대회 초록집
2021 .05
-
Executive Summary of Stroke Statistics in Korea 2018: A Report from the Epidemiology Research Council of the Korean Stroke Society
대한뇌졸중학회지
2019 .01
-
Pneumococcal meningitis complicated by otomastoiditis and pneumocephalus confounding an acute ischemic stroke diagnosis
Journal of Neurocritical Care
2021 .01
-
Trends in Incident and Recurrent Rates of First-Ever Ischemic Stroke in Taiwan between 2000 and 2011
대한뇌졸중학회지
2016 .01
-
Clinical Variables and Genetic Risk Factors Associated with the Acute Outcome of Ischemic Stroke: A Systematic Review
대한뇌졸중학회지
2019 .01
-
Intensity of Statin Treatment in Korean Patients with Acute Myocardial Infarction and Very Low LDL Cholesterol
지질·동맥경화학회지
2019 .01
-
Lipid-Lowering Efficacy and Safety of a New Generic Rosuvastatin in Koreans: an 8-Week Randomized Comparative Study with a Proprietary Rosuvastatin
지질·동맥경화학회지
2020 .01
-
Combination of Statin and Ezetimibe versus Statin Monotherapy on Cardiovascular Disease and Type 2 Diabetes Incidence among Adults with Impaired Fasting Glucose: a Propensity- Matched Nationwide Cohort Study
지질·동맥경화학회지
2021 .09
-
국내 성인환자에서 이상지질혈증 약물치료와 골다공증 상관성
한국임상약학회지
2021 .12
-
스타틴과 당뇨병 발생 위험
대한의사협회지
2017 .01
-
Effect of Rosuvastatin on Coronary Flow Reserve in Hypertensive Patients at Cardiovascular Risk
Journal of Cardiovascular Imaging
2021 .01
-
The Relationship between Delirium and Statin Use According to Disease Severity in Patients in the Intensive Care Unit
Clinical Psychopharmacology and Neuroscience
2023 .02
-
Clinical Benefit of Statins in Korean Patients with Acute Myocardial Infarction: Experience of the Korea Acute Myocardial Infarction Registry
지질·동맥경화학회지
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0