지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background and Purpose The pathophysiology of post-stroke depression (PSD) is complex and may differ according to an individual’s mood immediately after stroke. Here, we compared the therapeutic response and clinical characteristics of PSD at a later stage between patients with and without depression immediately after stroke. Methods This study involved a post hoc analysis of data from EMOTION (ClinicalTrials.gov NCT01278498), a placebo-controlled, double-blind trial that examined the efficacy of escitalopram (10 mg/day) on PSD and other emotional disturbances among 478 patients with acute stroke. Participants were classified into the Baseline-Blue (patients with baseline depression at the time of randomization, defined per the Montgomery-Asberg Depression Rating Scale [MADRS] ≥8) or the Baseline-Pink groups (patients without baseline depression). We compared the efficacy of escitalopram and predictors of 3-month PSD (MADRS ≥8) between these groups. Results There were 203 Baseline-Pink and 275 Baseline-Blue patients. The efficacy of escitalopram in reducing PSD risk was more pronounced in the Baseline-Pink than in the Baseline-Blue group (P for interaction=0.058). Several risk factors differentially affected PSD development based on the presence of baseline depression (P for interaction <0.10). Cognitive dysfunction was an independent predictor of PSD in the Baseline-Blue, but not in the Baseline-Pink group, whereas the non-use of escitalopram and being female were more strongly associated with PSD in the Baseline-Pink group. Conclusions Responses to escitalopram and predictors of PSD 3 months following stroke differed based on the presence of baseline depression. Our data suggest that PSD pathophysiology is heterogeneous; therefore, different therapeutic strategies may be needed to prevent PSD emergence following stroke.
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참고문헌 (27)
참고문헌 신청
Robinson RG / 2016 / Post-stroke depression: a review / Am J Psychiatry 173:221~231
Kim JS / 2000 / Poststroke depression and emotional incontinence: correlation with lesion location / Neurology 54:1805~1810
Parikh RM / 1990 / The impact of poststroke depression on recovery in activities of daily living over a 2-year follow-up / Arch Neurol 47:785~789
House A / 1991 / Mood disorders in the year after first stroke / Br J Psychiatry 158:83~92
Wade DT / 1987 / Depressed mood after stroke. A community study of its frequency / Br J Psychiatry 151:200~205
Kim JS / 2000 / Poststroke depression and emotional incontinence: correlation with lesion location / Neurology 54:1805~1810
Parikh RM / 1990 / The impact of poststroke depression on recovery in activities of daily living over a 2-year follow-up / Arch Neurol 47:785~789
House A / 1991 / Mood disorders in the year after first stroke / Br J Psychiatry 158:83~92
Wade DT / 1987 / Depressed mood after stroke. A community study of its frequency / Br J Psychiatry 151:200~205
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