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논문 기본 정보

자료유형
학술저널
저자정보
Cheolmin Shin (Korea University) Sang Won Jeon (Department of Psychiatry Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine) Seung-Hoon Lee (Veterans Health Service Medical Center) Chi-Un Pae (The Catholic University of Korea) Narei Hong (Hallym University Sacred Heart Hospital) Hyun Kook Lim (The Catholic University of Korea) Ashwin A Patkar (Duke University) Prakash S. Masand (Global Medical Education) Hyonggin An (Department of Biostatistics Korea University College of Medicine) Changsu Han (Korea University)
저널정보
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제21권 제1호
발행연도
2023.2
수록면
135 - 146 (12page)
DOI
10.9758/cpn.2023.21.1.135

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초록· 키워드

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Objective: Anxious depression is associated with greater chronicity, higher severity of symptoms, more severe functional impairment, and poor response to drug treatment. However, evidence for first-choice antidepressants in patients with anxious depression is limited. This study aimed to compare the efficacy and safety of escitalopram, desvenlafaxine, and vortioxetine in the acute treatment of anxious depression. Methods: Patients (n = 124) with major depressive disorder and high levels of anxiety were randomly assigned to an escitalopram treatment group (n = 42), desvenlafaxine treatment group (n = 40), or vortioxetine treatment group (n = 42) in a 6-week randomized rater-blinded head-to-head comparative trial. Changes in overall depressive and anxiety symptoms were assessed using the 17-item Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Rating Scale (HAMA), respectively. Results: Patients demonstrated similar baseline-to-endpoint improvement in scores and similar response and remission rates for HAMD and HAMA. Analysis of the individual HAMD items revealed that desvenlafaxine significantly reduced anxiety somatic scores (p = 0.013) and hypochondriasis scores (p = 0.014) compared to escitalopram. With respect to the individual HAMA items, desvenlafaxine treatment showed significantly lower scores for respiratory symptoms (p = 0.013) than escitalopram treatment and cardiovascular symptoms (p = 0.005) than vortioxetine treatment. The treatments were well tolerated, with no significant differences. Conclusion: Our results indicated no significant differences in the efficacy and tolerability of escitalopram, desvenlafax ine, and vortioxetine in this subtype of patients with anxious depression during the acute phase of treatment.

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