지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제21권 제1호
- 발행연도
- 2018.1
- 수록면
- 34 - 42 (9page)
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초록· 키워드
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Purpose: Monogenic inflammatory bowel disease (IBD) patients do not respond to conventional therapy and are associated with a higher morbidity. We summarized the clinical characteristics of monogenic IBD patients and com-pared their clinical outcomes to that of non-monogenic IBD patients.Methods: We performed a retrospective cohort study of all children ＜18 years old who were diagnosed with IBD between 2005 and 2016. A total of 230 children were enrolled. Monogenic IBD was defined as a presentation age less than 6 years old with confirmation of a genetic disorder. We subdivided the groups into monogenic IBD (n=18), non-monogenic very early-onset IBD (defined as patients with a presentation age ＜6 years old without a confirmed genetic disorder, n=12), non-monogenic IBD (defined as all patients under 18 years old excluding monogenic IBD, n=212), and severe IBD (defined as patients treated with an anti-tumor necrosis factor excluding monogenic IBD, n=92). We compared demographic data, initial pediatric Crohn disease activity index/pediatric ulcerative colitis activ-ity index (PCDAI/PUCAI) score, frequency of hospitalizations, surgical experiences, and height and weight under 3rd percentile among the patients enrolled.Results: The initial PCDAI/PUCAI score (p＜0.05), incidence of surgery per year (p＜0.05), and hospitalization per year (p＜0.05) were higher in the monogenic IBD group than in the other IBD groups. Additionally, the proportion of children whose weight and height were less than the 3rd percentile (p＜0.05 and p＜0.05, respectively) was also higher in the monogenic IBD group. Conclusion: Monogenic IBD showed more severe clinical manifestations than the other groups.
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참고문헌 (26)
참고문헌 신청
Loddo I / 2015 / Inflammatory bowel disease: genetics, epigenetics, and pathogenesis / Front Immunol 6:551
서정기 / 2011 / 소아기에 발병하는 염증성장질환(IBD)은 성인 IBD와 다른 질환인가? - 조기발병 소아 IBD의 역학적, 임상적, 유전학적 특성 및 치료 시 고려 사항- / Pediatric Gastroenterology, Hepatology & Nutrition 14(1):1~25
Seo JK / 1992 / Inflammatory bowel disease in children: clinical, endoscopic, radiologic and histopathologic investigation / J Korean Med Sci 7:221~235
Uhlig HH / 2013 / Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease / Gut 62:1795~1805
Kotlarz D / 2012 / Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy / Gastroenterology 143:347~355
서정기 / 2011 / 소아기에 발병하는 염증성장질환(IBD)은 성인 IBD와 다른 질환인가? - 조기발병 소아 IBD의 역학적, 임상적, 유전학적 특성 및 치료 시 고려 사항- / Pediatric Gastroenterology, Hepatology & Nutrition 14(1):1~25
Seo JK / 1992 / Inflammatory bowel disease in children: clinical, endoscopic, radiologic and histopathologic investigation / J Korean Med Sci 7:221~235
Uhlig HH / 2013 / Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease / Gut 62:1795~1805
Kotlarz D / 2012 / Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy / Gastroenterology 143:347~355
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