지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제20권 제4호
- 발행연도
- 2015.1
- 수록면
- 198 - 205 (8page)
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초록· 키워드
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Purpose: Vitamin D status was evaluated in children with epilepsy taking anticonvulsants to determine the prevalence and risk factors of vitamin D deficiency.
Methods: This study was designed as both a cross-sectional and a retrospective cohort study. A sum of 198 children who were diagnosed with epilepsy at the Department of Pediatrics in Dankook University Hospital was included. Their serum vitamin D levels were reviewed based on clinical information, and analyzed using IBM SPSS ver. 20.0.
Results: One hundred twenty-four children (62.6%) had vitamin D deficiency. Two risk factors were associated: winter to spring season (odds ratio [OR], 3.71; 95% confidence interval [CI], 1.835–7.492) and age more than 12 years (OR, 3.22; 95% CI, 1.377–7.542). Out of the 57 patients who were not vitamin D deficient at the time of initial assay, 47 patients (82.5%) became vitamin D deficient during followup.
The change of serum 25-hydroxy vitamin D3 (25(OH)D) levels during follow up showed a weak negative correlation with the duration of medication (r=–0.283, P=0.033). Medication duration was longer and brain magnetic resonance imaging (MRI) abnormality, abnormal underlying conditions, and nonambulatory status were more frequently present in twenty-five patients (44%) who showed a decline of more than 15 ng/mL during follow-up (P<0.05).
Conclusion: Vitamin D deficiency is common in children with epilepsy taking anticonvulsants, especially in adolescents more than 12 years of age. This study emphasizes the regular monitoring of vitamin D level, especially in the presence of longer duration of medication, brain MRI abnormality, abnormal underlying conditions, and nonambulatory status.
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참고문헌 (25)
참고문헌 신청
Chapuy MC / 1997 / Prevalence of vitamin D insufficiency in an adult normal population / Osteoporos Int 7 : 439 ~ 443
Fong CY / 2014 / Vitamin D deficiency among children with epilepsy in South Queensland / J Child Neurol 29 : 368 ~ 373
Giovannucci E. / 2010 /
Gordon CM / 2008 / Prevalence of vitamin D deficiency among healthy infants and toddlers / Arch Pediatr Adolesc Med 162 : 505 ~ 512
Gorham ED / 2005 / Vitamin D and prevention of colorectal cancer / J Steroid Biochem Mol Biol 97 : 179 ~ 194
Fong CY / 2014 / Vitamin D deficiency among children with epilepsy in South Queensland / J Child Neurol 29 : 368 ~ 373
Giovannucci E. / 2010 /
Gordon CM / 2008 / Prevalence of vitamin D deficiency among healthy infants and toddlers / Arch Pediatr Adolesc Med 162 : 505 ~ 512
Gorham ED / 2005 / Vitamin D and prevention of colorectal cancer / J Steroid Biochem Mol Biol 97 : 179 ~ 194
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