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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제21권 제3호
- 발행연도
- 2016.1
- 수록면
- 119 - 125 (7page)
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초록· 키워드
오류제보하기
Exosomes are extracellular vesicles that contain molecules that regulate the metabolic functions of adjacent or remote cells. Recent in vitro, in vivo and clinical studies support the hypothesis that exosomes released from various cell types play roles in the progression of metabolic disorders including type 2 diabetes. Based on this concept and advances in other diseases, the proteins, mRNA, microRNA and lipids in exosomes isolated from biological fluids have been proposed as biomarkers in metabolic disorders. However, several problems with the development of clinically applicable biomarkers have not been resolved. In this review, the biologic functions of exosomes are briefly introduced, and we discuss the technical and practical pros and cons of different methods of exosome isolation for the identification of exosomal biomarkers of metabolic disorders. Standardization of preanalytical variables and isolation of high-purity exosomes from fully characterized biological fluids will be necessary for the identification of useful exosomal biomarkers that can provide insights into the pathogenic mechanisms of complications of metabolic syndrome and of whole-body metabolism.
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등록된 정보가 없습니다.
참고문헌 (58)
참고문헌 신청
Guescini M / 2010 / C2C12 myoblasts release microvesicles containing mtDNA and proteins involved in signal transduction / Exp Cell Res 316:1977~1984
Aoki N / 2007 / Identification and characterization of microvesicles secreted by 3T3-L1 adipocytes: redox- and hormonedependent induction of milk fat globule-epidermal growth factor 8-associated microvesicles / Endocrinology 148:3850~3862
Conde-Vancells J / 2008 / Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes. / J Proteome Res 7:5157~5166
R aiborg C / 2009 / The ESCRT machiner y in endosomal sorting of ubiquitylated membrane proteins / Nature 458:445~452
Baietti MF / 2012 / Syndecan-syntenin-ALIX regulates the biogenesis of exosomes / Nat Cell Biol 14:677~685
Aoki N / 2007 / Identification and characterization of microvesicles secreted by 3T3-L1 adipocytes: redox- and hormonedependent induction of milk fat globule-epidermal growth factor 8-associated microvesicles / Endocrinology 148:3850~3862
Conde-Vancells J / 2008 / Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes. / J Proteome Res 7:5157~5166
R aiborg C / 2009 / The ESCRT machiner y in endosomal sorting of ubiquitylated membrane proteins / Nature 458:445~452
Baietti MF / 2012 / Syndecan-syntenin-ALIX regulates the biogenesis of exosomes / Nat Cell Biol 14:677~685
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