지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 598 - 606 (9page)
이용수
초록· 키워드
오류제보하기
ARF is an alternative reading frame product of the INK4a/ARF locus, inactivated in numerous human cancers. ARF is a key regulator of cellular senescence, an irreversible cell growth arrest that suppresses tumor cell growth. It functions by sequestering MDM2 (a p53 E3 ligase) in the nucleolus, thus activating p53. Besides MDM2, ARF has numerous other interacting partners that induce either cellular senescence or apoptosis in a p53-independent manner. This further complicates the dynamics of the ARF network. Expression of ARF is frequently disrupted in human cancers, mainly due to epigenetic and transcriptional regulation. Vigorous studies on various transcription factors that either positively or negatively regulate ARF transcription have been carried out. However, recent focus on posttranslational modifications, particularly ubiquitination, indicates wider dynamic controls of ARF than previously known. In this review, we discuss the role and dynamic regulation of ARF in senescence and cancer.
목차
등록된 정보가 없습니다.
참고문헌 (87)
참고문헌 신청
Kim WY / 2006 / The regulation of INK4/ARF in cancer and aging / Cell 127:265~275
Gil J / 2006 / Regulation of the INK4b-ARFINK4a tumour suppressor locus: all for one or one for all / Nat Rev Mol Cell Biol 7:667~677
Haupt Y / 1997 / Mdm2promotes the rapid degradation of p53 / Nature 387:296~299
Pomerantz J / 1998 / The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53 / Cell 92:713~723
Kamijo T / 1998 / Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2 / Proc Natl Acad Sci U S A 95:8292~8297
Gil J / 2006 / Regulation of the INK4b-ARFINK4a tumour suppressor locus: all for one or one for all / Nat Rev Mol Cell Biol 7:667~677
Haupt Y / 1997 / Mdm2promotes the rapid degradation of p53 / Nature 387:296~299
Pomerantz J / 1998 / The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53 / Cell 92:713~723
Kamijo T / 1998 / Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2 / Proc Natl Acad Sci U S A 95:8292~8297
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
강우 사상의 시·공간적 규모 특성을 반영한 호우중심형 ARF 산정
한국수자원학회 학술발표회
2018 .01
-
Acoustofluidic Separation of Bioparticles using SAW-induced ARF
대한기계학회 춘추학술대회
2024 .06
-
강우 형태에 따른 호우중심형 ARF의 스케일 특성 비교
대한토목학회 학술대회
2019 .10
-
레이더 및 지상 합성강우장에 대한 지속시간-재현기간별 호우중심형 ARF
한국수자원학회 학술발표회
2016 .01
-
Spatial Interpolation of Rainfall by Areal Reduction Factor (ARF) Analysis for Hancheon Watershed
한국수자원학회 학술발표회
2015 .01
-
이중편파 레이더 면적감소계수를 이용한 낙동강 유역내 면적별 설계홍수량 산정
한국수자원학회 학술발표회
2015 .01
-
지속시간 및 재현기간에 따른 레이더 강우 호우중심형 ARF의 산정
한국수자원학회 학술발표회
2017 .01
-
Cellular senescence: a promising strategy for cancer therapy
BMB Reports
2019 .01
-
3 Dimensional Augmented Reality Flight for Drones
International journal of internet, broadcasting and communication : IJIBC
2018 .01
-
MicroRNA controls of cellular senescence
BMB Reports
2018 .01
-
수문학적 특성을 적용한 제주 도심지유역의 ARF 산정 및 분석
한국수자원학회 학술발표회
2017 .01
-
Juxtacrine regulation of cellular senescence
BMB Reports
2019 .01
-
Fabrication of Silicone Rubber‑Based Biochip for Disinfection Under Deep‑UV Light by ArF Excimer Laser‑Induced Photodissociation
Electronic Materials Letters
2021 .01
-
Cellular senescence, aging, and age-related disease: Special issue of BMB Reports in 2019
BMB Reports
2019 .01
-
Annexin A2 as a regulator of the cellular senescence and apoptosis through p21
한국생물공학회 학술대회
2015 .04
-
Dynamics of the mobile insert helix in the domain III-IV of Aux/IAA17 probed by site-directed spin labeling and paramagnetic NMR spectroscopy
Journal of the Korean Magnetic Resonance Society
2015 .01
-
Evogliptin, a dipeptidyl peptidase-4 inhibitor, attenuates pathological retinal angiogenesis by suppressing vascular endothelial growth factor-induced Arf6 activation
Experimental and Molecular Medicine
2020 .10
-
Particulate matter-induced senescence of skin keratinocytes involves oxidative stress-dependent epigenetic modifications
Experimental and Molecular Medicine
2019 .01
-
Alternative Polyadenylation(APA)-mediated 3’UTR Lengthening Contributes to Cellular Senescence
한국생물공학회 학술대회
2023 .04
-
Disruption of nucleocytoplasmic trafficking as a cellular senescence driver
Experimental and Molecular Medicine
2021 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0