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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 429 - 436 (8page)
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Fructose in the form of sucrose and high fructose corn syrup is absorbed by the intestinal transporter and mainly metabolized in the small intestine. However, excess intake of fructose overwhelms the absorptive capacity of the small intestine, leading to fructose malabsorption. Carbohydrate response element-binding protein (ChREBP) is a basic helix-loop-helix leucine zipper transcription factor that plays a key role in glycolytic and lipogenic gene expression in response to carbohydrate consumption. While ChREBP was initially identified as a glucose-responsive factor in the liver, recent evidence suggests that ChREBP is essential for fructoseinduced lipogenesis and gluconeogenesis in the small intestine as well as in the liver. We recently identified that the loss of ChREBP leads to fructose intolerance via insufficient induction of genes involved in fructose transport and metabolism in the intestine. As fructose consumption is increasing and closely associated with metabolic and gastrointestinal diseases, a comprehensive understanding of cellular fructose sensing and metabolism via ChREBP may uncover new therapeutic opportunities. In this mini review, we briefly summarize recent progress in intestinal fructose metabolism, regulation and function of ChREBP by fructose, and delineate the potential mechanisms by which excessive fructose consumption may lead to irritable bowel syndrome.
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참고문헌 (76)
참고문헌 신청
Hanover LM / 1993 / Manufacturing, composition, and applications of fructose / Am J Clin Nutr 58:724S~732S
Bray GA / 2004 / Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity / Am J Clin Nutr 79:537~543
Powell ES / 2016 / Added Sugars Intake Across the Distribution of US Children and Adult Consumers: 1977-2012 / J Acad Nutr Diet 116:1543~1550
이행신 / 2014 / 한국인의 총 당류 섭취실태 평가: 2008~2011년 국민건강영양조사 자료를 이용하여 / Journal of Nutrition and Health 47(4):268~276
Elliott SS / 2002 / Fructose, weight gain, and the insulin resistance syndrome / Am J Clin Nutr 76:911~922
Bray GA / 2004 / Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity / Am J Clin Nutr 79:537~543
Powell ES / 2016 / Added Sugars Intake Across the Distribution of US Children and Adult Consumers: 1977-2012 / J Acad Nutr Diet 116:1543~1550
이행신 / 2014 / 한국인의 총 당류 섭취실태 평가: 2008~2011년 국민건강영양조사 자료를 이용하여 / Journal of Nutrition and Health 47(4):268~276
Elliott SS / 2002 / Fructose, weight gain, and the insulin resistance syndrome / Am J Clin Nutr 76:911~922
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