지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 566 - 571 (6page)
이용수
초록· 키워드
오류제보하기
Weight loss ≥ 5 percent is sufficient to significantly reduce health risks for obese people; therefore, development of novel weight loss compounds with reduced toxicity is urgently required. After screening of natural compounds with antiadipogenesis properties in 3T3-L1 cells, we determined that kahweol, a coffee-specific diterpene, inhibited adipogenesis. Kahweol reduced lipid accumulation and expression levels of adipogenesis and lipid accumulation-related factors. Levels of phosphorylated AKT and phosphorylated JAK2, that induce lipid accumulation, decreased in kahweol-treated cells. Particularly, kahweol treatment significantly increased AMP-activated protein kinase (AMPK) activation. We revealed that depletion of AMPK alleviated reduction in lipid accumulation from kahweol treatment, suggesting that inhibition of lipid accumulation by kahweol is dependent on AMPK activation. We detected more rapid reduction in blood glucose levels in mice administrated kahweol than in control mice. We suggest that kahweol has anti-obesity effects and should be studied further for possible therapeutic applications.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Apovian CM / 2015 / Pharmacological management of obesity: an endocrine Society clinical practice guideline / J Clin Endocrinol Metab 100 : 342 ~ 362
Bray GA / 2013 / Why do we need drugs to treat the patient with obesity? / Obesity (Silver Spring) 21 : 893 ~ 899
Cardenas C / 2011 / Medina, Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene / PLoS One 6 : e23407 ~
Cheung BM / 2013 / Safety of antiobesity drugs / Ther Adv Drug Saf 4 : 171 ~ 181
Fumimoto R / 2012 / The coffee diterpene kahweol prevents osteoclastogenesis via impairment of NFATc1 expression and blocking of Erk phosphorylation / J Pharmacol Sci 118 :
Bray GA / 2013 / Why do we need drugs to treat the patient with obesity? / Obesity (Silver Spring) 21 : 893 ~ 899
Cardenas C / 2011 / Medina, Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene / PLoS One 6 : e23407 ~
Cheung BM / 2013 / Safety of antiobesity drugs / Ther Adv Drug Saf 4 : 171 ~ 181
Fumimoto R / 2012 / The coffee diterpene kahweol prevents osteoclastogenesis via impairment of NFATc1 expression and blocking of Erk phosphorylation / J Pharmacol Sci 118 :
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
AMPK activators: mechanisms of action and physiological activities
Experimental and Molecular Medicine
2016 .01
-
Natural Product O Improve the Muscle Loss via AMPK Activation in Aged Mice
한국생물공학회 학술대회
2024 .09
-
Regulation and function of AMPK in physiology and diseases
Experimental and Molecular Medicine
2016 .01
-
Tschimganidine reduces lipid accumulation through AMPK activation and alleviates high-fat diet-induced metabolic diseases
BMB Reports
2023 .04
-
Anti-obesity Activity of Fermented Coffee Ground and Inhibition of Lipid Accumulation of 3T3-L1
한국생물공학회 학술대회
2022 .09
-
AMPK suppresses Th2 cell responses by repressing mTORC2
Experimental and Molecular Medicine
2022 .08
-
The implications of signaling lipids in cancer metastasis
Experimental and Molecular Medicine
2018 .01
-
Rac-mediated actin remodeling and myosin II are involved in KATP channel trafficking in pancreatic β-cells
Experimental and Molecular Medicine
2015 .01
-
MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis
Experimental and Molecular Medicine
2016 .01
-
Stevia Isolated Compounds and Theasaponin E1 Synergistic Effects on Adipogenesis and Lipogenesis Inhibition by Suppression of the Obesity Promoting Signaling Pathways
한국생물공학회 학술대회
2022 .09
-
AGS위암세포에서 AMPK/Akt/GSK-3β 신호경로를 통한 삼채추출물의 항암효과
KSBB Journal
2018 .12
-
Lipid Conjugates for Artificial Lipid Membranes
한국생물공학회 학술대회
2022 .04
-
AMPK alleviates high uric acid-induced Na+-K+-ATPase signaling impairment and cell injury in renal tubules
Experimental and Molecular Medicine
2019 .01
-
Chain Flexibility of Medicinal Lipids Determines Their Selective Partitioning into Lipid Droplets
한국생물공학회 학술대회
2023 .10
-
A549 폐암 세포주에서 AMPK/Akt/mTOR 신호 경로를 통한 소나무 담쟁이덩굴 에탄올 추출물의 Apoptosis 유도효과
KSBB Journal
2019 .09
-
Attenuation of Obesity with Synergistic Therapeutic and Preventive Effects of Natural Products by Suppression of the Associated Promoting Signaling Pathways
한국생물공학회 학술대회
2021 .04
-
The role of lipids in the pathogenesis and treatment of type 2 diabetes and associated co-morbidities
BMB Reports
2016 .01
-
Melatonin and doxorubicin synergistically enhance apoptosis via autophagy-dependent reduction of AMPKα1 transcription in human breast cancer cells
Experimental and Molecular Medicine
2021 .09
-
Investigating Lysozyme-Lipid Interactions for Improved Tear Film Lipid Layer Functionality
한국생물공학회 학술대회
2023 .04
-
Attenuation of Obesity with Synergistic Therapeutic and Preventive Effects of Natural Products by Suppression of Associated Promoting Signaling Pathways
한국생물공학회 학술대회
2021 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0