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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 193 - 199 (7page)
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Degenerative retinal diseases affect millions of people worldwide, which can lead to the loss of vision. However, therapeutic approaches that can reverse this process are limited. Recent efforts have allowed the possibility of the stem cell-based regeneration of retinal cells and repair of injured retinal tissues. Although the direct differentiation of pluripotent stem cells into terminally differentiated photoreceptor cells comprises one approach, a series of studies revealed the intrinsic regenerative potential of the retina using endogenous retinal stem cells. Muller glial cells, ciliary pigment epithelial cells, and retinal pigment epithelial cells are candidates for such retinal stem cells that can differentiate into multiple types of retinal cells and be integrated into injured or developing retina. In this review, we explore our current understanding of the cellular identity of these candidate retinal stem cells and their therapeutic potential for cell therapy against degenerative retinal diseases.
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참고문헌 (24)
참고문헌 신청
Austin CP / 1995 / Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch / Development 121 : 3637 ~ 3650
Ballios BG / 2012 / The adult retinal stem cell is a rare cell in the ciliary epithelium whose progeny can differentiate into photoreceptors / Biol Open 1 : 237 ~ 246
Becker S / 2013 / Acquisition of RGC phenotype in human Muller glia with stem cell characteristics is accompanied by upregulation of functional nicotinic acetylcholine recept
Bernardos RL / 2007 / Late-stage neuronal progenitors in the retina are radial Muller glia that function as retinal stem cells / J Neurosci 27 : 7028 ~ 7040
Coles BL / 2004 / Facile isolation and the characterization of human retinal stem cells / Proc Natl Acad Sci U S A 101 : 15772 ~ 15777
Ballios BG / 2012 / The adult retinal stem cell is a rare cell in the ciliary epithelium whose progeny can differentiate into photoreceptors / Biol Open 1 : 237 ~ 246
Becker S / 2013 / Acquisition of RGC phenotype in human Muller glia with stem cell characteristics is accompanied by upregulation of functional nicotinic acetylcholine recept
Bernardos RL / 2007 / Late-stage neuronal progenitors in the retina are radial Muller glia that function as retinal stem cells / J Neurosci 27 : 7028 ~ 7040
Coles BL / 2004 / Facile isolation and the characterization of human retinal stem cells / Proc Natl Acad Sci U S A 101 : 15772 ~ 15777
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