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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 388 - 393 (6page)
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Although brown adipose tissue is important with regard to energy balance, the molecular mechanism of brown adipocyte differentiation has not been extensively studied. Specifically, regulation factors at the level of protein modification are largely unknown. In this study, we examine the changes in the expression level of enzymes which are involved in protein lysine methylation during brown adipocyte differentiation.
Several enzymes, in this case SUV420H2, PRDM9, MLL3 and JHDM1D, were found to be up-regulated. On the other hand, Set7/9 was significantly down-regulated. In the case of SUV420H2, the expression level increased sharply during brown adipocyte differentiation, whereas the expression of SUV420H2 was marginally enhanced during the white adipocyte differentiation. The knock-down of SUV420H2 caused the suppression of brown adipocyte differentiation, as compared to a scrambled control. These results suggest that SUV420H2, a methyltransferase, is involved in brown adipocyte differentiation, and that the methylation of protein lysine is important in brown adipocyte differentiation.
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참고문헌 (31)
참고문헌 신청
Park A / 2014 / Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells / World J Stem Cells 6:33~42
Harms M / 2013 / Brown, beige fat:development, function and therapeutic potential / Nature Med 19:1252~1263
Yao X / 2011 / Recent progress in the study of brown adipose tissue / Cell Biosci 1:35
배광희 / 2012 / Involvement of protein tyrosine phosphatases in adipogenesis: New anti-obesity targets? / BMB Reports 45(12):700~706
Whetstine JR / 2014 / Methylation : a multifaceted modification – looking at transcription and beyond / Biochim Biophys Acta 1839:1351~1352
Harms M / 2013 / Brown, beige fat:development, function and therapeutic potential / Nature Med 19:1252~1263
Yao X / 2011 / Recent progress in the study of brown adipose tissue / Cell Biosci 1:35
배광희 / 2012 / Involvement of protein tyrosine phosphatases in adipogenesis: New anti-obesity targets? / BMB Reports 45(12):700~706
Whetstine JR / 2014 / Methylation : a multifaceted modification – looking at transcription and beyond / Biochim Biophys Acta 1839:1351~1352
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