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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 164 - 174 (11page)
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Mitochondria are cytosolic organelles essential for generating energy and maintaining cell homeostasis. Despite their critical function, the handful of proteins expressed by the mitochondrial genome is insufficient to maintain mitochondrial structure or activity. Accordingly, mitochondrial metabolism is fully dependent on factors encoded by the nuclear DNA, including many proteins synthesized in the cytosol and imported into mitochondria via established mechanisms.
However, there is growing evidence that mammalian mitochondria can also import cytosolic noncoding RNA via poorly understood processes. Here, we summarize our knowledge of mitochondrial RNA, discuss recent progress in understanding the molecular mechanisms and functional impact of RNA import into mitochondria, and identify rising challenges and opportunities in this rapidly evolving field.
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참고문헌 (28)
참고문헌 신청
Attardi G / 1971 / Mitochondrial ribssome in HeLa cells / Nat New Biol 229 : 133 ~ 136
Bandiera S / 2011 / Nuclear outsourcing of RNA interference components to human mitochondria / PLoS One 6 : e20746 ~
Burzio VA / 2009 / Expression of a family of noncoding mitochondrial RNAs distinguishes normal f
Chacinska A / 2009 / Importing mitochondrial proteins: machineries and mechanisms / Cell 138 : 628 ~ 644
Chang DD / 1987 / A mammalian mitochondrial RNA processing activity contains nucleusencoded RNA / Science 235 : 1178 ~ 1184
Bandiera S / 2011 / Nuclear outsourcing of RNA interference components to human mitochondria / PLoS One 6 : e20746 ~
Burzio VA / 2009 / Expression of a family of noncoding mitochondrial RNAs distinguishes normal f
Chacinska A / 2009 / Importing mitochondrial proteins: machineries and mechanisms / Cell 138 : 628 ~ 644
Chang DD / 1987 / A mammalian mitochondrial RNA processing activity contains nucleusencoded RNA / Science 235 : 1178 ~ 1184
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