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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 541 - 548 (8page)
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초록· 키워드
오류제보하기
Cardiomyopathy is an inherited or acquired disease of the myocardium, which can result in severe ventricular dysfunction. Mitochondrial dysfunction is involved in the pathological process of cardiomyopathy. Many dysfunctions in cardiac mitochondria are consequences of mutations in nuclear or mitochondrial DNA followed by alterations in transcriptional regulation, mitochondrial protein function, and mitochondrial dynamics and energetics, presenting with associated multisystem mitochondrial disorders. To ensure correct diagnosis and optimal management of mitochondrial dysfunction in cardiomyopathy caused by multiple pathogenesis, multidisciplinary approaches are required, and to integrate between clinical and basic sciences, ideal translational models are needed. In this review, we will focus on experimental models to provide insights into basic mitochondrial physiology and detailed underlying mechanisms of cardiomyopathy and current mitochondria-targeted therapies for cardiomyopathy.
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등록된 정보가 없습니다.
참고문헌 (97)
참고문헌 신청
Yoshizawa A / 2012 / Autoimmunity against M(2)muscarinic acetylcholine receptor induces myocarditis and leads to a dilated cardiomyopathy-like phenotype / Eur J Immunol 42:1152~1163
Palmer JW / 1977 / Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle / J Biol Chem 252:8731~8739
Shin G / 1989 / Detection of mitochondrial membrane damages in myocardial ischemia with ESR spin labeling technique / J Mol Cell Cardiol 21:1029~1036
Palmer JW / 1985 / Biochemical differences between subsarcolemmal and interfibrillar mitochondria from rat cardiac muscle: effects of procedural manipulations / Arch Biochem Biophys 236:691~702
Hoppel CL / 1982 / Hamster cardiomyopathy. A defect in oxidative phosphorylation in the cardiac interfibrillar mitochondria / J Biol Chem 257:1540~1548
Palmer JW / 1977 / Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle / J Biol Chem 252:8731~8739
Shin G / 1989 / Detection of mitochondrial membrane damages in myocardial ischemia with ESR spin labeling technique / J Mol Cell Cardiol 21:1029~1036
Palmer JW / 1985 / Biochemical differences between subsarcolemmal and interfibrillar mitochondria from rat cardiac muscle: effects of procedural manipulations / Arch Biochem Biophys 236:691~702
Hoppel CL / 1982 / Hamster cardiomyopathy. A defect in oxidative phosphorylation in the cardiac interfibrillar mitochondria / J Biol Chem 257:1540~1548
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