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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 35 - 46 (12page)
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Despite enduring diverse insults, mitochondria maintain normal functions through mitochondrial quality control. However, the failure of mitochondrial quality control resulting from excess damage and mechanical defects causes mitochondrial dysfunction, leading to various human diseases. Recent studies have reported that mitochondrial defects are found in Alzheimer’s disease (AD) and worsen AD symptoms. In AD pathogenesis, mitochondrial dysfunction-driven generation of reactive oxygen species (ROS) and their contribution to neuronal damage has been widely studied. In contrast, studies on mitochondrial dysfunction-associated inflammatory responses have been relatively scarce. Moreover, ROS produced upon failure of mitochondrial quality control may be linked to the inflammatory response and influence the progression of AD. Thus, this review will focus on inflammatory pathways that are associated with and initiated through defective mitochondria and will summarize recent progress on the role of mitochondria-mediated inflammation in AD. We will also discuss how reducing mitochondrial dysfunction-mediated inflammation could affect AD.
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참고문헌 (145)
참고문헌 신청
Smith RA / 2012 / Mitochondrial pharmacology / Trends Pharmacol Sci 33:341~352
유승민 / 2018 / A Molecular Approach to Mitophagy and Mitochondrial Dynamics / Molecules and Cells 41(1):18~26
Suomalainen A / 2018 / Mitochondrial diseases : the contribution of organelle stress responses to pathology / Nat Rev Mol Cell Biol 19:77~92
Leyns CEG / 2017 / TREM2deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy / Proc Natl Acad Sci U S A 114:11524~11529
Corder EH / 1993 / Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families / Science 261:921~923
유승민 / 2018 / A Molecular Approach to Mitophagy and Mitochondrial Dynamics / Molecules and Cells 41(1):18~26
Suomalainen A / 2018 / Mitochondrial diseases : the contribution of organelle stress responses to pathology / Nat Rev Mol Cell Biol 19:77~92
Leyns CEG / 2017 / TREM2deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy / Proc Natl Acad Sci U S A 114:11524~11529
Corder EH / 1993 / Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families / Science 261:921~923
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