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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 71 - 77 (7page)
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The activation of glial cells in the spinal cord has been contribute to the initiation and maintenance of pain facilitation induced by peripheral inflammation and nerve injury. The present study investigated effects of botulinum toxin type A (BoNT-A), injected subcutaneously or intracisternally, on the expression of microglia and astrocytes in rats. Complete Freund’s Adjuvant (CFA)-induced inflammation was employed as an orofacial chronic inflammatory pain model. A subcutaneous injection of 40 μL CFA into the vibrissa pad was performed under 3% isoflurane anesthesia in SD rats. Immunohistochemical analysis for changes in Iba1 (a microglia marker) and GFAP (an astrocyte marker), were performed 5 days after CFA injection.
Subcutaneous injection of CFA produced increases in Iba1 and GFAP expression, in the ipsilateral superficial lamia I and II in the medullary dorsal horn of rats. Subcutaneous treatment with BoNT-A attenuated the up-regulation of Iba1 and GFAP expressions induced by CFA injection. Moreover, intracisternal injection of BoNT-A also attenuated the up-regulated Iba1 and GFAP expressions. These results suggest that the anti-nociceptive action of BoNT-A is mediated by modulation activation of glial cells, including microglia and astrocyte.
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등록된 정보가 없습니다.
참고문헌 (57)
참고문헌 신청
Ren K / 2010 / Interactions between the immune and nervous systems in pain / Nat Med 16:1267~1276
Xie YF / 2007 / Involvement of glia in central sensitization in trigeminal subnucleus caudalis(medullary dorsal horn) / Brain Behav Immun 21:634~641
Ahn DK / 1998 / Central NO is involved in the antinociceptive action of intracisternal antidepressants in freely moving rats / Neurosci Lett 243:105~108
Ahn DK / 2005 / Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving rats / Pain 117:204~213
Wang XM / 2002 / Effect of antisense knock-down of alpha(2a)-and alpha(2c)-adrenoceptors on the antinociceptive action of clonidine on trigeminal nociception in the rat / Pain 98:27~35
Xie YF / 2007 / Involvement of glia in central sensitization in trigeminal subnucleus caudalis(medullary dorsal horn) / Brain Behav Immun 21:634~641
Ahn DK / 1998 / Central NO is involved in the antinociceptive action of intracisternal antidepressants in freely moving rats / Neurosci Lett 243:105~108
Ahn DK / 2005 / Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving rats / Pain 117:204~213
Wang XM / 2002 / Effect of antisense knock-down of alpha(2a)-and alpha(2c)-adrenoceptors on the antinociceptive action of clonidine on trigeminal nociception in the rat / Pain 98:27~35
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