지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 301 - 312 (12page)
이용수
초록· 키워드
오류제보하기
Patients with neurogenic lower urinary tract dysfunction (NLUTD) experience urinary incontinence with or without difficult urination, which might promote recurrent urinary tract infection (UTI) and exacerbate upper urinary tract function. Nonetheless, appropriate bladder management has been shown to reduce urological complications and improve quality of life. In addition to pharmacological therapy and surgical intervention, botulinum toxin A (BoNT-A) has been widely utilized in NLUTD. The therapeutic efficacy of detrusor BoNT-A injections for neurogenic detrusor overactivity due to spinal cord injury (SCI), multiple sclerosis, or other central nervous system lesions, such as cerebrovascular accident, Parkinson disease, early dementia, and pediatric NLUTD due to myelomeningocele, has been well established, with repeated BoNT-A injections every 6 to 9 months being necessary to maintain its therapeutic effects. Urethral BoNT-A injection can decrease urethral sphincter resistance and facilitate efficient voiding in patients with NLUTD who wish to preserve self-voiding. Detrusor BoNT-A injection can also decrease the occurrence of autonomic dysreflexia in patients with SCI, even after failed augmentation enterocystoplasty, with additional benefits including reduced UTI episodes and preserved renal function with repeated injections. However, this treatment does have some side effects. Complete informed consent for BoNT-A injection therapy with full disclosure of its potential complications should therefore be obtained before this procedure is undertaken.
목차
등록된 정보가 없습니다.
참고문헌 (99)
참고문헌 신청
Dykstra DD / 1988 / Effects of botulinum A toxin on detrusor-sphincter dyssynergia in spinal cord injury patients / J Urol 139:919~922
Schurch B / 1996 / Botulinum-A toxin as a treatment of detrusor-sphincter dyssynergia : a prospective study in 24 spinal cord injury patients / J Urol 155:1023~1029
Dykstra DD / 1990 / Treatment of detrusor-sphincter dyssynergia with botulinum A toxin : a double-blind study / Arch Phys Med Rehabil 71:24~26
de Sèze M / 2002 / Botulinum a toxin and detrusor sphincter dyssynergia : a double-blind lidocaine-controlled study in 13 patients with spinal cord disease / Eur Urol 42:56~62
Kuo HC / 2003 / Botulinum A toxin urethral injection for the treatment of lower urinary tract dysfunction / J Urol 170:1908~1912
Schurch B / 1996 / Botulinum-A toxin as a treatment of detrusor-sphincter dyssynergia : a prospective study in 24 spinal cord injury patients / J Urol 155:1023~1029
Dykstra DD / 1990 / Treatment of detrusor-sphincter dyssynergia with botulinum A toxin : a double-blind study / Arch Phys Med Rehabil 71:24~26
de Sèze M / 2002 / Botulinum a toxin and detrusor sphincter dyssynergia : a double-blind lidocaine-controlled study in 13 patients with spinal cord disease / Eur Urol 42:56~62
Kuo HC / 2003 / Botulinum A toxin urethral injection for the treatment of lower urinary tract dysfunction / J Urol 170:1908~1912
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