지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 350 - 357 (8page)
이용수
초록· 키워드
오류제보하기
Glial cells are receiving much attention since they have been recognized as important regulators of many aspects of brain function and disease. Recent evidence has revealed that two different glial cells, astrocytes and microglia, control synapse elimination under normal and pathological conditions via phagocytosis. Astrocytes use the MEGF10 and MERTK phagocytic pathways, and microglia use the classical complement pathway to recognize and eliminate unwanted synapses. Notably, glial phagocytosis also contributes to the clearance of disease-specific protein aggregates, such as ${\beta}$-amyloid, huntingtin, and ${\alpha}$-synuclein. Here we reivew recent findings showing that glial cells are active regulators in brain functions through phagocytosis and that changes in glial phagocytosis contribute to the pathogenesis of various neurodegenerative diseases. A better understanding of the cellular and molecular mechanisms of glial phagocytosis in healthy and diseased brains will greatly improve our current approach in treating these diseases.
목차
등록된 정보가 없습니다.
참고문헌 (95)
참고문헌 신청
Akiyama, H. / 2000 / Inflammation and Alzheimer's disease / Neurobiol. Aging 21:383~421
Allen, N. J. / 2005 / Signaling between glia and neurons: focus on synaptic plasticity / Curr. Opin. Neurobiol. 15:542~548
Allen, N. J. / 2012 / Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors / Nature 486:410~414
Araque, A. / 1999 / Astrocyte-induced modulation of synaptic transmission / Can. J. Physiol. Pharmacol. 77:699~706
Austin, S. A. / 2006 / ${\alpha}$ -synuclein expression modulates microglial activation phenotype / J. Neurosci. 26:10558~10563
Allen, N. J. / 2005 / Signaling between glia and neurons: focus on synaptic plasticity / Curr. Opin. Neurobiol. 15:542~548
Allen, N. J. / 2012 / Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors / Nature 486:410~414
Araque, A. / 1999 / Astrocyte-induced modulation of synaptic transmission / Can. J. Physiol. Pharmacol. 77:699~706
Austin, S. A. / 2006 /
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
신경아교세포와 조현병
생물정신의학
2015 .01
-
Early Postnatal Valproic Acid Exposure Increase the Protein Level of Astrocyte Markers in Frontal Cortex of Rat
Clinical Psychopharmacology and Neuroscience
2018 .01
-
The Neuro-Protective Effect of the Methanolic Extract of Perilla frutescens var. japonica and Rosmarinic Acid against H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Stress in C6 Glial Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
A Single Intraperitoneal Injection of Endotoxin Changes Glial Cells in Rats as Revealed by Positron Emission Tomography Using [<sup>11</sup>C]PK11195
Nuclear medicine and molecular imaging : NMMI
2018 .01
-
Effect of Various Agents on Oral Bacterial Phagocytosis in THP-1 Cells
International Journal of Oral Biology
2018 .01
-
Stress Changes the Spatial Arrangement of Neurons and Glial Cells of Medial Prefrontal Cortex and Sertraline and Curcumin Prevent It
PSYCHIATRY INVESTIGATION
2015 .01
-
Changes in glial and blood-brain barrier on effective transcranial direct current stimulation (tDCS) after transient cerebral ischemia
한국실험동물학회 학술발표대회 논문집
2019 .01
-
A study on glial scar formation in spinal cord injury model
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Histamine is required for macrophage phagocytic activity to elimination of bacteria
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Co-culture platform for neuron-astrocyte interaction using optogenetic modulation
Biomedical Engineering Letters (BMEL)
2022 .11
-
Sequential Activation of AMPA Receptors and Glial Cells in a Pain Model of Lumbar Spine Disc Herniation
Annals of Rehabilitation Medicine
2020 .01
-
Botulinum Toxin Type A Attenuates Activation of Glial Cells in Rat Medullary Dorsal Horn with CFA-induced Inflammatory Pain
International Journal of Oral Biology
2015 .01
-
Production of transgenic pigs using a pGFAP-CreERT2/EGFPLoxP inducible system for central nervous system disease models
Journal of Veterinary Science
2018 .05
-
Ginsenoside Rb1 increases macrophage phagocytosis through p38 mitogen-activated protein kinase/Akt pathway
Journal of Ginseng Research
2019 .06
-
Caffeic Acid의 항산화 활성 및 Amyloid beta와 LPS에 의한 C6 Glial 세포의 산화적 스트레스 보호 효과
생약학회지(Korean Journal of Pharmacognosy)
2015 .06
-
Antidepressant effects of ginsenoside Rf on behavioral change in the glial degeneration model of depression by reversing glial loss
Journal of Ginseng Research
2020 .07
-
신경아교세포와 기분장애
생물정신의학
2015 .01
-
The Oligomeric Form of Amyloid Beta Triggers Astrocyte Activation, Independent of Neurons
전남의대학술지
2024 .01
-
Etoposide Induces Mitochondrial Dysfunction and Cellular Senescence in Primary Cultured Rat Astrocytes
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Engelhardtia chrysolepis의 라디칼 소거능 및 신경세포의 산화 스트레스 보호효과
생약학회지(Korean Journal of Pharmacognosy)
2016 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0