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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제48권 제2호
- 발행연도
- 2018.1
- 수록면
- 70 - 83 (14page)
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초록· 키워드
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Purpose: The aim of this study was to evaluate the capacity of single and combined applications of the bark of the stems and roots of Magnolia officinalis Rehd. et Wils. (Magnoliae Cortex) and Zea mays L. (maize) to modulate inflammation in RAW 264.7 cells stimulated with Porphyromonas gingivalis . Methods: RAW 264.7 cells were stimulated with P. gingivalis , and Magnoliae Cortex and/ or maize was added. Cytotoxicity and the capacity to modulate inflammation were determined with a methylthiazol tetrazolium (MTT) assay, nitrite production, enzyme-linked immunosorbent assay (ELISA), and western blotting. Results: Treatment with Magnoliae Cortex and/or maize inhibited nuclear transcription factor κB (NF-κB) pathway activation and nuclear p44/42 mitogen-activated protein kinase (MAPK) and inducible nitric oxide synthase (iNOS) protein expression in P. gingivalis stimulated RAW 264.7 cells. Moreover, the treatments suppressed cytokines (prostaglandin E2 [PGE2], interleukin [IL]-1β, and IL-6) and nitrite production. Conclusions: Both Magnoliae Cortex and maize exerted an anti-inflammatory effect on P. gingivalis -stimulated RAW 264.7 cells, and this effect was more pronounced when the extracts were combined. These findings show that these extracts may be beneficial for slowing the progression of periodontal disease.
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참고문헌 (38)
참고문헌 신청
Socransky SS / 1992 / The bacterial etiology of destructive periodontal disease: current concepts / J Periodontol 63(Suppl 4S):322~331
Yagan A / 2014 / Effect of low-dose doxycycline on serum oxidative status, gingival antioxidant levels, and alveolar bone loss in experimental periodontitis in rats / J Periodontol 85:478~489
Nibali L / 2015 / Aggressive periodontitis: microbes and host response, who to blame? / Virulence 6:223~228
Paquette DW / 2000 / Modulation of host inflammatory mediators as a treatment strategy for periodontal diseases / Periodontol 2000 24:239~252
Zawawi KH / 2010 / Moesin-induced signaling in response to lipopolysaccharide in macrophages / J Periodontal Res 45:589~601
Yagan A / 2014 / Effect of low-dose doxycycline on serum oxidative status, gingival antioxidant levels, and alveolar bone loss in experimental periodontitis in rats / J Periodontol 85:478~489
Nibali L / 2015 / Aggressive periodontitis: microbes and host response, who to blame? / Virulence 6:223~228
Paquette DW / 2000 / Modulation of host inflammatory mediators as a treatment strategy for periodontal diseases / Periodontol 2000 24:239~252
Zawawi KH / 2010 / Moesin-induced signaling in response to lipopolysaccharide in macrophages / J Periodontal Res 45:589~601
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